. . . . "0"^^ . . . . "0"^^ . "2"^^ . "2"^^ . "1"^^ . . . "Cyklick\u00E9 oligopeptidy ovliv\u0148uj\u00EDc\u00ED sekreci r\u016Fstov\u00E9ho hormonu a proces st\u00E1rnut\u00ED." . . . "Cyclic Oligopeptides Influencing a Secretion of Growth Hormone and a Process of Ageing."@en . "C\u00EDlem projektu je synt\u00E9za a studium biologick\u00E9 potence nov\u00FDch cyklick\u00FDch peptid\u016F ovliv\u0148uj\u00EDc\u00EDch uvol\u0148ov\u00E1n\u00ED r\u016Fstov\u00E9ho hormonu (GH) a reguluj\u00EDc\u00EDch proces st\u00E1rnut\u00ED. Z\u00E1m\u011Br vych\u00E1z\u00ED z navr\u017Een\u00E9 pseudocyklick\u00E9 konformace potentn\u00EDho line\u00E1rn\u00EDho hexapeptidu His-D-Trp-Ala-Trp-D-Phe-Lys, kterou jsme potvrdili synt\u00E9zou jeho cyklick\u00E9ho analogu s agonistick\u00FDm \u00FA\u010Dinkem pro uvoln\u011Bn\u00ED GH, kter\u00FD rovn\u011B\u017E zpomaloval st\u00E1rnut\u00ED i experiment\u00E1ln\u00EDch my\u0161\u00ED. Design a synt\u00E9za nov\u00FDch analogick\u00FDch cyklopeptid\u016F jsou nezbytn\u00E9 pro porozum\u011Bn\u00ED ejich interakci s receptory, zv\u00FD\u0161en\u00ED odolnosti i peptid\u016F v\u016F\u010Di \u0161t\u011Bpen\u00ED enzymy a t\u00EDm prodlou\u017Een\u00ED jejich aktivn\u00EDho p\u016Fsoben\u00ED na metabolismus r\u016Fstov\u00E9ho hormonu a r\u016Fstov\u00FDch faktor\u016F zodpov\u011Bdn\u00FDch za \u0159\u00EDzen\u00ED koordinovan\u00E9ho r\u016Fstu a za \u0159\u00EDzen\u00ED regenera\u010Dn\u00EDch proces\u016F \u017Eiv\u00E9m organismu. Zm\u011Bny struktury cyklopeptid\u016F a jejich biologick\u00E1 potence budou konfrontov\u00E1ny s v\u00FDsledky konforma\u010Dn\u00EDch studi\u00ED pomoc\u00ED fyzik\u00E1ln\u011B-chemick\u00FDch metod a v\u00FDpo\u010Dt\u016F molekul\u00E1rn\u00ED dynamiky." . . "GA203/94/0678" . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/94/0678"^^ .