"The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . "0"^^ . . . . . . "0"^^ . "2011-12-31+01:00"^^ . "2015-03-02+01:00"^^ . "1"^^ . "Vypracov\u00E1n\u00ED vhodn\u00E9 metodiky pro stanoven\u00ED konfigurace chir\u00E1ln\u00EDch slou\u010Denin obsahuj\u00EDc\u00EDch jako chir\u00E1ln\u00ED centrum atom s\u00EDry, dus\u00EDku nebo fosforu (sulfoxidy, N-oxidy, fosfinoxidy, fosfin\u00E1ty a fosfon\u00E1ty). Aplikace metodiky u biologicky aktivn\u00EDch l\u00E1tek." . . . " sulfoxidy" . . . . . " fosfon\u00E1ty" . . . . "14"^^ . "konfigurace, stereochemie, NMR v roztoku a v pevn\u00E9 f\u00E1zi, sulfoxidy, N-oxidy, fosfinoxidy, fosfon\u00E1ty,"@en . "14"^^ . "2011-04-16+02:00"^^ . . . "GA203/09/1919" . . "The development of a suitable methodology for configuration determination of chiral biologically active compounds containing sulfur, nitrogen, or phosphorus atom as a chiral center (sulfoxides, N-oxides, phosphine oxides, phosphinates and phosphonates). The combination of NMR experiments in solution and in solid state with quantum chemical calculations (geometry optimization, calculation of NMR chemical shifts and spin-spin coupling constants) will be used. We would like to explore the effects of magnetic anisotropy of S-O, N-O and P=O functional groups on chemical shifts and coupling constants of the other atoms in the molecule. In the frame of the project we would like to investigate geminal coupling constants\u00A0J(P-C-C) and J(P-C-H) and their dependence on the structure and configuration of modified nucleotide phosphonates containing an asymmetric carbon in the neighboring position to the phosphorus atom.\u00A0"@en . " stereochemie" . " NMR v roztoku a v pevn\u00E9 f\u00E1zi" . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo v\u00FDte\u010Dn\u011B, jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . " N-oxidy" . "konfigurace" . "Development of methods for configuration determination at chiral sulfur, nitrogen or phosphorus atom using NMR spectroscopy and ab initio calculations"@en . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/09/1919"^^ . "2009-01-01+01:00"^^ . "V\u00FDvoj metody stanoven\u00ED konfigurace na chir\u00E1ln\u00EDch centrech obsahuj\u00EDc\u00EDch atom s\u00EDry, dus\u00EDku nebo fosforu pomoc\u00ED NMR spektroskopie a ab initio v\u00FDpo\u010Dt\u016F" . . " fosfinoxidy" .