" termosenzitivn\u00ED" . . . "9"^^ . "9"^^ . . . . "Attachment of natural macromolecules to synthetic ones may lead to new %22smart%22 materials changing their properties in response to external stimuli. Synthesis and study of block copolymers consisting of hydrophilic synthetic polymers and peptides prepared by solid phase synthesis is suggested. The peptide block, thanks to its tailor-made primary structure, would enable the whole system to react to changes of its environment (e.g., temperature, pH, ionic strength). The peptide sequences designed for the synthesis of the copolymers will be derived from important natural proteins (elastin, kinesin) with corresponding structural motifs (?-helix, \u00DF-spiral, coiled-coil). The polymer block can be represented, e.g., by poly(ethylene glycol) and the peptide part of the copolymer, e.g. by peptide (VPGXG)n , derived from elastin. Intermolecular structures (micelles, liposomes) will be formed as a result of peptide conformational changes upon increase of temperature. These properties could be utilized for preparation of new systems for controlled drug release and delivery."@en . "synt\u00E9za peptid\u016F" . . "0"^^ . "2015-03-02+01:00"^^ . . "synt\u00E9za peptid\u016F; hybridn\u00ED kopolymery; termosenzitivn\u00ED; supramolekul\u00E1rn\u00ED nanostruktury"@en . "1"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/08/0543"^^ . . "0"^^ . " hybridn\u00ED kopolymery" . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo podle pl\u00E1nu jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . "The project gone according to plan both in terms of expertise and in terms of disbursement of funds."@en . "Hybrid macromolecular systems based on hydrophilic polymers and stimuli-responsive peptides"@en . . . "2008-01-01+01:00"^^ . "C\u00EDle projektu jsou n\u00E1vrh, synt\u00E9za a charakterizace hybridn\u00EDch kopolymer\u016F slo\u017Een\u00FDch z hydrofiln\u00EDch syntetick\u00FDch polymer\u016F a peptid\u016F. Peptidov\u00E9 \u010D\u00E1sti budou p\u0159i zm\u011Bn\u011B teploty \u010Di pH podl\u00E9hat zm\u011Bn\u00E1m konformace vedouc\u00EDm ke vzniku nadmolekul\u00E1rn\u00EDch \u00FAtvar\u016F studovan\u00FDch fyzik\u00E1ln\u011B-chemick\u00FDmi metodami (NMR, LS)." . "2011-04-16+02:00"^^ . . . . "GA203/08/0543" . "Hybridn\u00ED makromolekul\u00E1rn\u00ED syst\u00E9my na b\u00E1zi hydrofiln\u00EDch polymer\u016F a peptid\u016F reaguj\u00EDc\u00EDch na vn\u011Bj\u0161\u00ED podn\u011Bty" . . . "2011-12-31+01:00"^^ . . . .