. "calixarenes" . . "Modul\u00E1rn\u00ED p\u0159\u00EDstup k enantioselektivn\u00EDm receptor\u016Fm chir\u00E1ln\u00EDch aniont\u016F ve vodn\u00E9m prost\u0159ed\u00ED" . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/06/1796"^^ . " (thio)ureas" . . . . "0"^^ . . "2008-12-31+01:00"^^ . . . "0"^^ . . "2"^^ . "New receptors have been designed based on completely new derivative of calix[4]arene skeleton in 1,3-alternate conformation. The new modular synthesis of whole array of receptor structures has been developed. Using it, new receptors capable of enantioselective recognition of anions in both organic and aqueous solutions are accessible. Preliminary experiments have shown, that receptors synthesized\u00A0have unique and tuneable structure of binding pocket with respect to its electronic, stereochemical as well as chiral features. Moreover, modular approach can be also used when water-soluble receptors are desired.\u00A0Receptors thus\u00A0obtained can also be immobilized onto solid surface for use as sensors for both organic and aqueous"@en . "2008-04-25+02:00"^^ . . "2009-10-22+02:00"^^ . "2"^^ . "1"^^ . . "GA203/06/1796" . . . . . "Modular approach to tuneable molecular receptors for enantioselective recognition of anions in water"@en . "2006-01-01+01:00"^^ . "C\u00EDlem projektu bylo p\u0159ipravit a prostudovat aniontov\u00E9 receptory s vhodnou rozpustnost\u00ED v pol\u00E1rn\u00EDch rozpou\u0161t\u011Bdlech, v ide\u00E1ln\u00EDm p\u0159\u00EDpad\u011B ver vod\u011B. Tohoto c\u00EDle dosa\u017Eeno nebylo. Poda\u0159ilo se ale nal\u00E9zt deriv\u00E1ty calixarenu, kter\u00E9 jsou schopny komplexovat aniont"@cs . "calixarenes; (thio)ureas; chiral recognition"@en . "The main goal of the project, to prepare and study anion receptors active in polar solvents up to water has not been fully achieved. Obn the other hand, new receptors for anions have been designed, preopared and studied with anion bind activity in dipola"@en . . . "Projekt se zab\u00FDv\u00E1 nov\u00FDmi receptory pro enantioselektivn\u00ED rozpozn\u00E1n\u00ED aniont\u016F na b\u00E1zi kalixaren\u016F. Na z\u00E1klad\u011B zcela nov\u00E9ho deriv\u00E1tu calix[4]arenu v 1,3-alternuj\u00EDc\u00ED konformaci jsou navr\u017Eeny modul\u00E1rn\u00ED struktury nov\u00FDch\u00A0receptor\u016F, schopn\u00FDch chir\u00E1ln\u00EDho rozpozn\u00E1n\u00ED aniont\u016F v prost\u0159ed\u00ED organick\u00E9m i vodn\u00E9m.\u00A0P\u0159edb\u011B\u017En\u00E9 experimenty potvrzuj\u00ED, \u017Ee navr\u017Een\u00E1 struktura je synteticky dostupn\u00E1 a \u0161iroce aplikovateln\u00E1 na mnoho p\u0159\u00EDbuzn\u00FDch struktur na\u00A0z\u00E1klad\u011B modul\u00E1rn\u00EDho syntetick\u00E9ho\u00A0p\u0159\u00EDstupu. Vlastnosti n\u011Bkter\u00FDch ji\u017E p\u0159ipraven\u00FDch receptor\u016F dokazuj\u00ED, \u017Ee nov\u00E1 struktura receptoru na b\u00E1zi kalix[4]arenu v 1,3-alternuj\u00EDc\u00ED konformaci m\u00E1 unik\u00E1tn\u00ED vlastnosti,\u00A0spo\u010D\u00EDvaj\u00EDc\u00ED v mo\u017Enosti velmi jemn\u011B ladit elektronick\u00E9, sterick\u00E9 i chir\u00E1ln\u00ED n\u00E1roky\u00A0vazebn\u00E9ho m\u00EDsta. Nav\u00EDc dovoluje m\u011Bnit v \u0161irok\u00FDch mez\u00EDch fyzik\u00E1ln\u00ED vlastnosti receptoru v\u010Detn\u011B rozpustnosti v organick\u00FDch i vodn\u00FDch prost\u0159ed\u00EDch i imobilizaci na tuh\u00E9m nosi\u010Di. \u00A0" .