" QSAR" . "Acute toxicity of binary and ternary mixtures of chemicals - QSAR analysis"@en . . . "binary mixtures" . " ternary mixtures" . . . "The plan suggested and approved was realized. The results were presented in conferences (one in czech, three in international ones) and in journals (four in czech and three in international ones).The validated log Pow-QSAR model was published for Tubifex"@en . "C\u00EDlem projektu je testovat akutn\u00ED toxicitu bin\u00E1rn\u00EDch sm\u011Bs\u00ED pr\u016Fmyslov\u011B d\u016Fle\u017Eit\u00FDch, chemick\u00FDch l\u00E1tek, hledat\u00A0zejm\u00E9na vyj\u00EDmky, kdy vz\u00E1jemn\u00E9 ovlivn\u011Bn\u00ED l\u00E1tek v \u00FA\u010Dinnosti nen\u00ED spojitou funkc\u00ED mol\u00E1rn\u00EDho zlomku l\u00E1tek ve sm\u011Bsi nebo podle\u00A0hodnoty mol\u00E1rn\u00EDho zlomku m\u016F\u017Ee j\u00EDt o potenciaci nebo inhibici pro stejnou sm\u011Bs l\u00E1tek, p\u0159\u00EDpadn\u011B jin\u00E9 vyj\u00EDmky. Tyto n\u00E1lezy mohou rozhoduj\u00EDc\u00EDm zp\u016Fsobem p\u0159isp\u011Bt k metodice odhadu risika exposice chemick\u00FDm l\u00E1tk\u00E1m.\u00A0Hledat z\u00E1konitosti, kter\u00E9 mohou p\u0159isp\u011Bt k odhadu o jak\u00FD druh interakce p\u016Fjde. Za druh\u00E9 pokusit se roz\u0161\u00ED\u0159it pozn\u00E1n\u00ED na tern\u00E1rn\u00ED sm\u011Bs l\u00E1tek. Bude pokra\u010Dov\u00E1no ve studiu zm\u011Bn koeficient\u016F distribuce sm\u011Bs\u00ED a rozd\u011Blovac\u00EDch koeficient\u016F\u00A0t\u011Bch\u017Ee chemick\u00FDch l\u00E1tek, jsou-li ve sm\u011Bsi mezi jejich vodn\u00FD roztok a vzduch a mezi n-oktanol a vodu.\u00A0 To bude dal\u0161\u00ED bod v\u00FDzkumu. Technikami anal\u00FDzy QSAR bude roz\u0161\u00ED\u0159ov\u00E1na mo\u017Enost popisu vztahu velikosti akutn\u00ED toxicity na mol\u00E1rn\u00EDm zlomku l\u00E1tek ve sm\u011Bsi a na koeficientech distribuce nebo rozd\u011Blovac\u00EDch koeficientech. Bude roz\u0161\u00ED\u0159eno pou\u017Eit\u00ED expres" . . . . . "2008-04-25+02:00"^^ . . "2006-01-01+01:00"^^ . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/06/1265"^^ . "2008-12-31+01:00"^^ . . . . "binary mixtures; ternary mixtures; QSAR; acute toxicity; partition coeficients"@en . "GA203/06/1265" . . "Akutn\u00ED toxicita bin\u00E1rn\u00EDch a tern\u00E1rn\u00EDch sm\u011Bs\u00ED chemick\u00FDch slou\u010Denin - anal\u00FDza QSAR" . "Navr\u017Een\u00FD a schv\u00E1len\u00FD pl\u00E1n na rok 2008 byl spln\u011Bn. V\u00FDsledky byly presentov\u00E1ny na konferenc\u00EDch (3 zahrani\u010Dn\u00ED, 1 dom\u00E1c\u00ED) a \u010Dasopisecky (4 v \u010De\u0161tin\u011B, z toho 1 v recensn\u00EDm \u0159\u00EDzen\u00ED, 1 zasl\u00E1na do tisku) a 3 pr\u00E1ce v zahrani\u010Dn\u00EDch \u010Dasopisech (1 v recensn\u00EDm \u0159\u00EDzen\u00ED)."@cs . "0"^^ . . "0"^^ . "1"^^ . . "The aim of the project is testing of acute toxicity of binary mixtures of industrial chemicals and, firstly,\u00A0to look especially about such exceptions when\u00A0a mutual influence of activities of\u00A0chemicals is not a continuous function of molar ratio of chemicals in the mixture. Another exception can be a fact that both potenciation and inhibition of activities\u00A0 exists in the same mixture, but depends on the molar ratio. This facts can significantly contribute to\u00A0risk assessment of exposure to chemicals. An attempt to find a way how to predict these irregularities will be made. Secondly, to expand the studies on changes in the acute toxicity of chemicals being in ternary mixtures. Studies on changes in partition coefficients of chemicals in\u00A0mixtures and in coefficients of distribution of the mixtures between aqueous and gaseous phases and between n-octanol and water will continue. Techniques of QSAR analysis\u00A0 will be used to derive an equation connecting acute toxicity in EC50 (Tubifex"@en . "11"^^ . "2009-10-22+02:00"^^ . " acute toxicity" . "11"^^ .