"5"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/05/0832"^^ . . "2005-01-01+01:00"^^ . "V\u00FDvoj potenci\u00E1ln\u00EDch l\u00E9\u010Div proti bakteri\u00E1ln\u00EDm infekc\u00EDm: N\u00EDzkomolekul\u00E1rn\u00ED antibakter\u00E1ln\u00ED peptidy" . "1"^^ . "1"^^ . "The project describes isolation, purification and biochemical characterization of several inducible peptides/proteins from the hemolymph of Neobelliera bullata. The (poly) peptides were isolated by a sequence of reversed-phase chromatography and elektrop"@en . . "0"^^ . "Finding potential drug candidates against bacterial infections: Low molecular mass antibacterial peptides"@en . . . "peptides; antibacterial; synthesis; SAR; bacteria; fungi"@en . . . . . . " bacteria" . . . " SAR" . . "The rapid spread of antibiotic resistance among bacterial strains has become a serious worldwide health problem. Since antibacterial peptides (ABPs) act in a manner entirely different from commercial antibiotics, they show very little tendency to elicit resistance and, consequently, have a real chance to complement or, in selected cases, substitute classical antibiotics. The so far limited success of ABPs as pharmaceuticals is partially due to the size of the peptides, bioavailability, metabolic stability, and immunogenicity. It is thus important to develop smaller ABPs in order to alleviate the concern of production cost and reduce potential immunogenic responses. The overall aim of this project is to synthesize new analogues of ABPs (with lessthan six residues) differing in the amino acid composition, chain lengths and presence of aromatic units, and to explore them and eventually their boronic acid derivatives as tools to reach the three goals: a) finding missing links between the structure"@en . . . "peptides" . "2007-05-02+02:00"^^ . "Rychle se roz\u0161i\u0159uj\u00EDc\u00ED rezistence \u0159ady bakteri\u00E1ln\u00EDch kmen\u016F v\u016F\u010Di antibiotik\u016Fm se st\u00E1v\u00E1 celosv\u011Btov\u00FDm zdravotn\u00EDm probl\u00E9mem. Pon\u011Bvad\u017E mechanismus p\u016Fsoben\u00ED antibakteri\u00E1ln\u00EDch peptid\u016F (ABP) na bakterie je odli\u0161n\u00FD od mechanismu, kter\u00FDm p\u016Fsob\u00ED komer\u010Dn\u00ED antibiotika, vyvol\u00E1n\u00ED rezistence je v p\u0159\u00EDpad\u011B potenci\u00E1ln\u00EDho pou\u017E\u00EDv\u00E1n\u00ED ABP jako terapeutik m\u00E1lo pravd\u011Bpodobn\u00E1. Proto maj\u00ED ABP re\u00E1lnou \u0161anci doplnit a v n\u011Bkter\u00FDch p\u0159\u00EDpadech nahradit klasick\u00E1 antibiotika. Dosud zna\u010Dn\u011B omezen\u00E1 \u00FAsp\u011B\u0161nost vyu\u017E\u00EDv\u00E1n\u00ED ABP jako l\u00E9\u010Div je p\u0159inejmen\u0161\u00EDm z \u010D\u00E1sti zp\u016Fsobena vysokou molekulovou hmotnost\u00ED dosud zn\u00E1m\u00FDch aktivn\u00EDch peptid\u016F, jejich p\u0159\u00EDstupnost\u00ED, omezenou metabolickou stabilitou a imunogenicitou. Je proto d\u016Fle\u017Eit\u00E9 v\u011Bnovat se v\u00FDzkumu a v\u00FDvoji nov\u00FDch n\u00EDzkomolekul\u00E1rn\u00EDch peptid\u016F, u kter\u00FDch lze p\u0159edpokl\u00E1dat jak ni\u017E\u0161\u00ED produk\u010Dn\u00ED n\u00E1klady tak sn\u00ED\u017Eenou tendenci k imunogen\u00EDm odezv\u00E1m. Z\u00E1m\u011Brem p\u0159edlo\u017Een\u00E9ho projektu je synt\u00E9za nov\u00FDch analog\u016F ABP (s maxim\u00E1ln\u00EDm pod\u00EDlem \u0161esti aminokyselin), li\u0161\u00EDc\u00EDch se slo\u017Een\u00EDm aminokyselin, d\u00E9lkou" . "2008-12-16+01:00"^^ . "Projekt \u0159e\u0161\u00ED isolaci, purifikaci a biochemickou characterizaci indukovan\u00FDch peptid\u016F/protein\u016F z hemolymfy masa\u0159ky Neobelliera bullata. (Poly) peptidy byly isolov\u00E1ny sequenc\u00ED reversn\u00ED HPLC a elektroforetick\u00FDch stup\u0148\u016F z hemolymfy larev immunizovan\u00FDch E.coli"@cs . . . "GA203/05/0832" . . . "2007-12-31+01:00"^^ . " synthesis" . "5"^^ . " antibacterial" . .