"http://www.isvav.cz/projectDetail.do?rowId=GA203/04/0178"^^ . . "Projekt je zam\u011B\u0159en na synt\u00E9zu fenyl a pyridylguanidiniov\u00FDch sol\u00ED, kter\u00E9 maj\u00ED potenci\u00E1ln\u00ED antifung\u00E1ln\u00ED aktivitu. V r\u00E1mci \u0159e\u0161en\u00ED bude syntetizov\u00E1na s\u00E9rie slou\u010Denin, u kter\u00E9 bude stanovena v\u00FD\u0161e zm\u00EDn\u011Bn\u00E1 biologick\u00E1 aktivita na skupin\u011B patogenn\u00EDch a nepatogenn\u00EDch pl\u00EDsn\u00ED. U p\u0159ipraven\u00FDch slou\u010Denin budou t\u00E9\u017E vypo\u010Dteny QSAR parametry a s jejich pomoc\u00ED hled\u00E1ny kvantitativn\u00ED vztahy mezi strukturou a \u00FA\u010Dinkem s v\u00FDhledov\u00FDm c\u00EDlem naj\u00EDt slou\u010Deniny pou\u017Eiteln\u00E9 v praxi. Z\u00EDskan\u00E9 vztahy t\u00E9\u017E mohou p\u0159in\u00E9st znalosti omechanismu \u00FA\u010Dinku testovan\u00FDch slou\u010Denin." . . "GA203/04/0178" . . . "Compounds from the group of substituted phenyl and pyridylguanidines were synthesized and tested during solving of the grant. Compounds shows very interesting antifungal activities, their MICs are in the range 1,95-31,25\u00A0umol/l. With regard to this activ"@en . "Antifung\u00E1ln\u00ED slou\u010Deniny. Studium vztah\u016F struktura - \u00FA\u010Dinek u fenyl a pyridylguanidin\u016F" . "V\u00A0r\u00E1mci \u0159e\u0161en\u00ED grantu byly p\u0159ipraveny a otestov\u00E1ny l\u00E1tky ze skupiny substituovan\u00FDch fenyl a pyridylguanidin\u016F. L\u00E1tky z\u00A0t\u00E9to s\u00E9rie vykazuj\u00ED velice zaj\u00EDmav\u00E9 antifung\u00E1ln\u00ED \u00FA\u010Dinky, jejich MIC\u00A0dosahuj\u00ED hodnot 1,95-31,25\u00A0umol/l. Vzhledem k t\u00E9to aktivit\u011B byly l\u00E1t"@cs . . "Neuvedeno."@en . "Project is focused on the synthesis of phenyl and pyridylguanidinium salts which have the potential antifungal activity. During the solving of the problem the series of compounds will be synthesized. The above mentioned biologic activity against the set of pathogenic and non-pathogenic fungi will be assessed at these compounds. QSAR parameters of the synthesized compounds will also be calculated and quantitive relationships between the structure and the activity will be found with the goal to find compounds usable in the practice. Obtained relationships can also bring the knowledge about the mechanism of action of tested compounds."@en . . . . . . . . "0"^^ . . "Antifungal compounds. Study of structure - activity relationships on phenyl and pyridylguanidines"@en . . . "1"^^ . . . "2007-10-16+02:00"^^ . . "2"^^ . "0"^^ . . . "2"^^ .