. . "Heterogeneous catalysis represents the driving force for a high number of industrial processes ranging from refineries to fine chemical applications. The development of new heterogeneous catalysts is extremely labour-intensive, however, onlyheterogeneous catalysts can limit the formation of enormous wastes. The proposed project is aimed at the employment of molecular sieve based catalysts for highly selective acylation of aromatic hydrocarbons combined with the utilization of various metalloaded catalysts for hydrogenation of carbonyl groups of different ketones. Both acylation and hydrogenation reactions belong to the most important group of reactions used in the synthesis of fine chemicals and pharmaceuticals. In the case of thesynthesis of Ibuprofen (pain-killer) two acylation steps are followed by two hydrogenation steps and this reaction system will be systematically investigated. Microporous molecular sieves of different structures and compositions will be applied to"@en . "2009-01-15+01:00"^^ . . "In the frame of this project reaction mechanisms of acylation and hydrogenation steps of Ibuprophen synthesis were investigated over acid and Pd-modified forms of zeolites. It was found that acid zeolites are able to catalyze toluene (model compound inst"@en . "V r\u00E1mci tohoto projektu byl studov\u00E1n reak\u010Dn\u00ED mechanismus acyla\u010Dn\u00EDch a hydrogena\u010Dn\u00EDch krok\u016F synt\u00E9zy Ibuprofenu na kysel\u00FDch form\u00E1ch zeolitick\u00FDch katalyz\u00E1tor\u016F nebo po jejich modifikaci palladiem. Poda\u0159ilo se prok\u00E1zat, \u017Ee kysel\u00E9 formy zeolit\u016F katalyzuj\u00ED acyl"@cs . . . "Synt\u00E9za speci\u00E1ln\u00EDch chemik\u00E1li\u00ED s vyu\u017Eit\u00EDm heterogenn\u00ED katal\u00FDzy" . . "Neuvedeno."@en . . . . . . . "Synthesis of fine chemicals via heterogenous catalysis"@en . . "0"^^ . . "GA203/03/0804" . "26"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA203/03/0804"^^ . . "26"^^ . "1"^^ . "Heterogenn\u00ED katal\u00FDza p\u0159edstavuje v sou\u010Dasn\u00E9 dob\u011B hnac\u00ED s\u00EDlu v cel\u00E9 \u0159ad\u011B chemick\u00FDch technologi\u00ED od zpracov\u00E1n\u00ED ropy a\u017E po synt\u00E9zu chemick\u00FDch specialit v\u010Detn\u011B l\u00E9\u010Div. V\u00FDvoj nov\u00FDch heterogenn\u00EDch katalyz\u00E1tor\u016F je nesm\u00EDrn\u011B pracn\u00FD a \u010Dasov\u011B n\u00E1ro\u010Dn\u00FD, ale jedin\u011Bpou\u017Eit\u00EDm vysoce selektivn\u00EDch heterogenn\u00EDch katalyz\u00E1tor\u016F je mo\u017En\u00E9 omezit obrovsk\u00E1 mno\u017Estv\u00ED vedlej\u0161\u00EDch produkt\u016F. C\u00EDlem navrhovan\u00E9ho projektu je vyu\u017Eit\u00ED katalyz\u00E1tor\u016F na b\u00E1zi molekulov\u00FDch s\u00EDt pro vysoce selektivn\u00ED acyla\u010Dn\u00ED reakce, sou\u010Dasn\u011B budou studov\u00E1nyr\u016Fzn\u00E9 katalyz\u00E1tory na b\u00E1zi kov\u016F pro selektivn\u00ED hydrogenaci karbonylov\u00E9 skupiny r\u016Fzn\u00FDch keton\u016F. Acyla\u010Dn\u00ED a hydrogena\u010Dn\u00ED reakce pat\u0159\u00ED mezi nejd\u016Fle\u017Eit\u011Bj\u0161\u00ED reakce pou\u017E\u00EDvan\u00E9 p\u0159i synt\u00E9ze chemick\u00FDch specialit a l\u00E9\u010Div. C\u00EDlem projektu je podrobn\u00E9 studium dvouacyla\u010Dn\u00EDch a dvou hydrogena\u010Dn\u00EDch krok\u016F, kter\u00E9 se prov\u00E1d\u00ED p\u0159i synt\u00E9ze Ibuprofenu (v\u00FDznamn\u00E9 antipyretikum). Mikropor\u00E9zn\u00ED molekulov\u00E1 s\u00EDta r\u016Fzn\u00FDch struktur budou vyu\u017Eita pro selektivn\u00ED acylaci benzenu halogenidem kyseliny isom\u00E1seln\u00E9 a acylaci isobutylbenzenu" . . . . . "1"^^ . .