"2009-01-15+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=GA203/03/0168"^^ . "GA203/03/0168" . "Phosphonic acid, phosphonic monoester and phosphinic acid pendant arm azacycles based on cyclen or cyclam will be synthesised and their coordination ability toward divalent and trivalent metal ions will be investigated. Those ligands are expected toprovide a faster complexation rate then their carboxylic analogues and complexes formed will retain a convenient thermodynamic and kinetic stability. The properties are desired in design of new ligands and complexes useful in nuclear medicine and as MRIcontrast agents. The main aim of the Project will be an understanding how ligand structure (size of macrocycle, number and/or kind of pendant arms, placement of the pendant arms) and, mainly, presence of phosphorus acid pendant arms influence propertiesof the complexes formed."@en . . . "Neuvedeno."@en . . "V r\u00E1mci projektu budou p\u0159ipraveny deriv\u00E1ty cyklenu a cyklamu obsahuj\u00EDc\u00ED skupinu fosfonovou, fosfinovou nebo monoestery fosfonov\u00E9 skupiny. U t\u011Bchto ligand\u016F bude zkoum\u00E1n zp\u016Fsob jejich koordinace k dvojmocn\u00FDm a trojmocn\u00FDm iont\u016Fm kov\u016F. D\u00E1 se p\u0159edpokl\u00E1dat, \u017Eetyto ligandy budou komplexovat ionty kov\u016F rychleji ne\u017E jejich karboxylov\u00E1 analoga a vznikl\u00E9 komplexy si zachovaj\u00ED dostate\u010Dn\u011B v\u00FDhodnou termodynamickou a kinetickou stabilitu. Uveden\u00E9 vlastnosti jsou podstatn\u00E9 pro v\u00FDvoj nov\u00FDch komplex\u016F, kter\u00E9 mohou b\u00FDtvyu\u017Eity v nukle\u00E1rn\u00ED medic\u00EDn\u011B nebo jako kontrastn\u00ED l\u00E1tky v tomografii magnetick\u00E9 resonance. Hlavn\u00EDm c\u00EDlem tohoto projektu bude pochopen\u00ED vlivu struktury ligandu (tj. velikosti makrocyklu, po\u010Dtu a druhu pendantn\u00EDch ramen a jejich um\u00EDst\u011Bn\u00ED na cyklick\u00E9mskeletu) a p\u0159edev\u0161\u00EDm vlivu fosforov\u00FDch pendantn\u00EDch ramen na vlastnosti vznikl\u00FDch komplex\u016F." . . . . . "0"^^ . "Kinetically Inert Complexes of Transition Metal and Lanthanide Ions. Design, Synthesis and Kinetic Investigations"@en . "C\u00EDlem projektu bylo zkoumat termodynamick\u00E9 a kinetick\u00E9 chov\u00E1n\u00ED komplex\u016F makrocyklick\u00FDch ligand\u016F s\u00A0ionty p\u0159echodn\u00FDch kov\u016F a lanthanoid\u016F. Byly syntetizov\u00E1ny nov\u00E9 ligandy zalo\u017Een\u00E9 na cyklenov\u00E9m nebo cyklamov\u00E9m skeletu maj\u00EDc\u00ED v\u00A0pendantn\u00EDm rameni alespo\u0148 jedn"@cs . . "Kineticky inertn\u00ED komplexy iont\u016F p\u0159echodn\u00FDch kov\u016F a lanthanoid\u016F. Design, synt\u00E9za a kinetick\u00E1 studia" . "The project was aimed to an investigation of thermodynamic and kinetic behaviours of complexes of macrocyclic ligands with transition metal and lanthanide ions. New ligands based on cyclen or cyclam skeleton having in the pendant arms at least one phosph"@en . "28"^^ . . . "28"^^ . . . . . "1"^^ . . "1"^^ . . . . .