. . "Z\u00E1m\u011Brem projektu je hledat nov\u00E9 katalyz\u00E1tory asymetrick\u00FDch synt\u00E9z odvozen\u00FDch od 2-fenylimidazolu. Byly navr\u017Eeny 4 z\u00E1kladn\u00ED struktury obsahuj\u00EDc\u00ED v molekule asymetrick\u00E9 centrum a sou\u010Dasn\u011B jeden nebo dva atomy, jejich\u017E prost\u0159ednictv\u00EDm m\u016F\u017Ee b\u00FDt vytvo\u0159ena vazba k substr\u00E1tu nebo nechir\u00E1ln\u00EDmu \u010Dinidlu. U t\u011Bchto l\u00E1tek budou studov\u00E1ny katalytick\u00E9 vlastnosti pro t\u0159i typy reakc\u00ED - solvol\u00FDzy ester\u016F s mo\u017Enost\u00ED kinetick\u00E9 resoluce racem\u00E1t\u016F, asymetrick\u00E9 redukce tetrahydridoboritanem sodn\u00FDm a asymetrick\u00E9 Michaelovy adice na vhodn\u00FDch modelov\u00FDch substr\u00E1tech. U nej\u00FA\u010Dinn\u011Bj\u0161\u00EDch slou\u010Denin pak bude studov\u00E1n vliv substituce v okol\u00ED asymetrick\u00E9ho centra, jemn\u011Bj\u0161\u00ED efekty substituce na fenylu v\u00E1zan\u00E9m v poloze 2 imidazolu a vliv rozpou\u0161t\u011Bdel na uveden\u00E9 reakce. Z\u00EDskan\u00E9 poznatkybudou aplikov\u00E1ny na optimalizaci synt\u00E9zy dvou pou\u017E\u00EDvan\u00FDch l\u00E9\u010Div." . . . . . . "0"^^ . "2008-06-02+02:00"^^ . "GA203/02/0750" . . . "In the first steps of the project, we had been looking for the ways that could lead to the synthesis of 2-fenylimidazol and its derivates with chiral centres. We emphasized those procedures which would enable insert chiral centre using enantiomeric precu"@en . "Deriv\u00E1ty 2-fenylimidazolu jako potencion\u00E1ln\u00ED katalyz\u00E1tory pro asymetrick\u00E9 synt\u00E9zy" . "The aim of the project is to look for new catalysts of asymmetrical syntheses derived from 2-phenylimidazole. Four basic structures have been suggested, containing one asymmetric centre in their molecule together with one or two atoms capable of bond formation with a substrate or a non-chiral reagent. Catalytic properties of these compounds will be studied in reactions of three types: solvolysis of esters with possible kinetic resolution of racemates, asymmetric reduction with sodium tetrahydridoborate, and asymmetric Michael additions to suitable model substrates. The most efficient compounds will then be studied with respect to substituent effects in the vicinity of asymmetric centre, the more subtle substituent effects in the phenyl group bound at 2-position of imidazole, and solvent effects on the reactions mentioned. The findings obtained will be applied to optimisation of syntheses of two medical drugs currently used."@en . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/02/0750"^^ . . . "Neuvedeno."@en . "1"^^ . . . . "1"^^ . . . "Derivates of 2-phenylmidazole as potential catalysators of asymmetric synthesis"@en . "7"^^ . "V\u00A0prvn\u00ED f\u00E1zi \u0159e\u0161en\u00ED projektu byly hled\u00E1ny cesty vedouc\u00ED k\u00A0synt\u00E9ze 2-fenylimidazolu a jeho deriv\u00E1t\u016F s\u00A0chir\u00E1ln\u00EDmi centry. D\u016Fraz byl kladen na postupy, jimi\u017E by bylo chir\u00E1ln\u00ED centrum vneseno s\u00A0pou\u017Eit\u00EDm dostupn\u00FDch enantiomern\u00EDch prekursor\u016F, zejm\u00E9na aminokyse"@cs . . "7"^^ . .