. . . . "2008-05-19+02:00"^^ . . "GA203/00/1310" . "0"^^ . "24"^^ . "24"^^ . . . . "V\u00FDznamn\u00FD a velmi zaj\u00EDmav\u00FD interdisciplin\u00E1rn\u00ED projekt spojuj\u00EDc\u00ED klasickou, ale n\u00E1ro\u010Dnou synt\u00E9zu kopolymer\u016F (z\u00E1kladem HEMA) a jejich model\u016F tak, aby se mohly st\u00E1t funk\u010Dn\u00ED sou\u010D\u00E1st\u00ED kultiva\u010Dn\u00EDch podlo\u017Eek pro p\u011Bstov\u00E1n\u00ED keratinocyt\u016F apod. (bun\u011B\u010Dn\u00E1 terapie ko\u017En"@cs . . . "1"^^ . . "Neuvedeno."@en . "1"^^ . "Grafting of cultured keratinocytes is used for the treatment of extensive skin defects and injuries. Keratinocytes are cultured with 3T3 mouse feeder cells, enzymatically separated from the cultivation support and grafted on the tulle grass to the wound bed which decreases their viability. In our previous research we developed new technology, which enables us grafting of keratinocytes (cultured wit lethally irradiated 3T3 feedcrs) directly on the cultivation support. This technology is under the clinicatrials. We have also preliminary results demonstrating that some saccharidic moietis adsorbed onto the polymer surface enable the attachment and proliferation of keratinocytes without the feeders. This modification decreases the time necessary for the treatment of patient and minimaze the risk of immunological complications. The main aim of this project is the optimation of the composition of bioactive carbohydrates and preparation of supports for the cultivation and direct grafting of these cells to"@en . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/00/1310"^^ . . "P\u0159\u00EDprava polymern\u00EDch nosi\u010D\u016F s kovalentn\u011B nav\u00E1zan\u00FDmi karbohydr\u00E1ty pro studium diferenciace keratynocyt\u016F a n\u00E1sledn\u00E9 terapeutick\u00E9 vyu\u017Eit\u00ED" . "Development of supports for keratinocyte grafting with covalently bound carbohydrates for study of keratinocyte differentiation and subsequentmedicalapplication"@en . . . . . "Transplantace kultivovan\u00FDch keratinocyt\u016F je pou\u017E\u00EDv\u00E1na pro l\u00E9\u010Dbu rozs\u00E1hl\u00FDch ko\u017En\u00EDch defekt\u016F a poran\u011Bn\u00ED. Keratinocyty jsou kultivov\u00E1ny spolu s podp\u016Frn\u00FDmi fibroplasty (my\u0161\u00ED 3T3 bu\u0148ky), enzymaticky odlou\u010Deny od kultiva\u010Dn\u00ED podlo\u017Eky a p\u0159eneseny na mastn\u00E9m tyluna rannou plochu, \u010D\u00EDm\u017E se sni\u017Euje jejich vitalita. Ji\u017E d\u0159\u00EDve jsme vyvinuli novou technologii, kter\u00E1 umo\u017E\u0148uje p\u0159enos keratinocyt\u016F (kultivovan\u00FDch spolu s let\u00E1ln\u011B oz\u00E1\u0159en\u00FDmi podp\u016Frn\u00FDmi bu\u0148kami) p\u0159\u00EDmo na kultiva\u010Dn\u00ED podlo\u017Ece, kter\u00E1 je nyn\u00ED klinicky testov\u00E1na. Z\u00E1rove\u0148 jsme p\u0159edb\u011B\u017En\u011B zjistili, \u017Ee n\u011Bkter\u00E9 sacharidy adsorbovan\u00E9 na povrchu polymern\u00EDho nosi\u010De umo\u017E\u0148uj\u00ED adhezi a proliferaci keratinocyt\u016F i bez p\u0159\u00EDtomnosti pomocn\u00FDch 3T3 my\u0161\u00EDch bun\u011Bk. C\u00EDlem tohoto projektu je proto zjistit optim\u00E1ln\u00ED slo\u017Een\u00ED biologicky aktivn\u00EDch sacharid\u016F a p\u0159ipravit kultiva\u010Dn\u00ED podlo\u017Eky s t\u011Bmito kovalentn\u011B nav\u00E1zan\u00FDmi substancemi. Na t\u011Bchto podlo\u017Ek\u00E1ch bude potom studov\u00E1na diferenciace keratinocyt\u016F jako d\u016Fle\u017Eit\u00FD p\u0159edpoklad pro klinick\u00E9 pou\u017Eit\u00ED." .