"Cyclodextrins and their analogs belong to the group of macrocyclic compounds that are capable to form inclusion complexes with other compounds. Thus they provide an opportunity to design and synthesize molecular receptors that are able to recognize structural features of different substrates, using noncovalent bonding interactions. The aim of this project is to elaborate the synthesis of a new group of cyclic oligosaccharides containing a or \u00DF (1->4) linked 2-amino-2-deoxyhexopyranoses, using orthogonally protected monosaccharide units. The modified cyclodextrin analogs of this type have not been described so far. The orthogonally protected 2-amino-2-deoxy cyclodextrin analogs obtained in this way allow for subsequent regioselective transformations. This fact will be used for modulation of their complexation abilities by regioselective introduction of different substituents and for construction of the enzyme-like models. Molecular mechanics and NMR spectroscopy methods will be used"@en . "Synt\u00E9za cyklick\u00FDch oligosacharid\u016F obsahuj\u00EDc\u00EDch 2-amino-2-deoxy-hexopyranosy a studium jejich komplexa\u010Dn\u00ED aktivity" . "Neuvedeno."@en . "14"^^ . . . "14"^^ . . "Synthesis of cyclic oligosaccharides containing 2-amino-2-deoxy-hexopyranoses and study of their complexation activity"@en . . . . . . . "1"^^ . . "GA203/00/0071" . "1"^^ . "2008-05-19+02:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA203/00/0071"^^ . . . "0"^^ . . "Projekt otev\u0159el zcela novou a origin\u00E1ln\u00ED problematiku p\u0159\u00EDpravy cyklick\u00FDch oligomer\u016F 2-amino-2-deoxygalakto- a mannopyranos spojen\u00FDch 1-4 glykosidickou vazbou. Byly optimalizov\u00E1ny jednotliv\u00E9 kroky synthesy line\u00E1rn\u00EDho oligosacharidu, ale \u010D\u00E1ste\u010Dn\u011B musela b\u00FD"@cs . . "Cyklodextriny a jejich analogy pat\u0159\u00ED do skupiny makrocyklick\u00FDch slou\u010Denin, kter\u00E9 jsou schopny tvo\u0159it intramolekul\u00E1rn\u00ED komplexy s jin\u00FDmi slou\u010Deninami. Poskytuj\u00ED tak mo\u017Enost navrhovat a syntetizovat molekul\u00E1rn\u00ED receptory schopn\u00E9 rozpoznat r\u016Fzn\u00E9 substr\u00E1ty pomoc\u00ED nevazebn\u00FDch interakc\u00ED. C\u00EDlem projektu je vypracovat synt\u00E9zu nov\u00E9 skupiny cyklick\u00FDch oligosacharid\u016F obsahuj\u00EDc\u00EDch alfa nebo beta(1->4) v\u00E1zan\u00E9 2- amino-2-deoxy-hexopyranosy z ortogon\u00E1ln\u011B chr\u00E1n\u011Bn\u00FDch monosacharidov\u00FDch jednotek. Takto modifikovan\u00E9 cyklodextrinov\u00E9 deriv\u00E1ty nebyly dosud pops\u00E1ny. Z\u00EDskan\u00E9 ortogon\u00E1ln\u011B chr\u00E1n\u011Bn\u00E9 2-amino-2- deoxy cyklodextrinov\u00E9 analogy umo\u017En\u00ED n\u00E1sledn\u00E9 regioselektivn\u00ED transformace. T\u00E9to skute\u010Dnosti bude vyu\u017Eito pro modulaci jejich komplexa\u010Dn\u00EDch schopnost\u00ED regioselektivn\u00EDmzaveden\u00EDm r\u016Fzn\u00FDch substituent\u016F a pro konstrukci enzymov\u00FDch model\u016F. Ke stanoven\u00ED geometrie transformovan\u00FDch cyklodextrin\u016F a pro mapov\u00E1n\u00ED jejich komplex\u016F bude vyu\u017Eito metod molekul\u00E1rn\u00ED mechaniky a NMR spektroskopie." . .