"C\u00EDlem projektu je p\u0159\u00EDprava n\u011Bkolika nov\u00FDch typ\u016F analog\u016F Watson-Crickov\u00FDch p\u00E1r\u016F b\u00E1z\u00ED a Hoogsteenov\u00FDch triplet\u016F. Prvn\u00ED typ analog\u016F budou p\u0159\u00EDmo v\u00E1zan\u00E9 purin-purin a purin-pyrimidin dimery biarylov\u00E9ho typu. Dal\u0161\u00ED analogy budou obsahovat spojnici obou baz\u00ED o r\u016Fzn\u00E9 d\u00E9lce, konfiguraci a konforma\u010Dn\u00ED flexibilit\u011B (nap\u0159. ethynyliden, cis/trans-ethenyliden, o-/p-fenylen atd.). Rovn\u011B\u017E pl\u00E1nujeme p\u0159\u00EDpravu 'trimer\u016F' obsahuj\u00EDc\u00ED t\u0159i purinov\u00E1 j\u00E1dra s centr\u00E1ln\u00ED benzenovou nebo triazinovou jednotkou. Jako meziprodukty budouslou\u017Eit 6-alkynyl- puriny, kter\u00E9 budou vyu\u017Eity tak\u00E9 k p\u0159\u00EDprav\u011B konjug\u00E1t\u016F purin\u016F s redoxn\u00EDmi chinoidn\u00EDmi syst\u00E9my. U v\u00FDsledn\u00FDch l\u00E1tek bude studov\u00E1na p\u0159edev\u0161\u00EDm jejich biologick\u00E1 aktivita (protivirov\u00E1 a protin\u00E1dorov\u00E1), ale tak\u00E9 n\u011Bkter\u00E9 jejich v\u00FDznamn\u00E9 vlastnosti, nap\u0159. atropoizomerie a axi\u00E1ln\u00ED chiralita u l\u00E1tek biarylov\u00E9ho typu atd. V\u00FDsledky projektu by m\u011Bly p\u0159in\u00E9st krom\u011B prostudov\u00E1n\u00ED biologick\u00E9 aktivity nov\u00FDch analog\u016F v\u00FDznamn\u00E9ho biochemick\u00E9ho syst\u00E9mu i p\u0159\u00EDsp\u011Bvek k metodice cross-coupling reakc\u00ED a" . "Synt\u00E9za purin-purinov\u00FDch a purin-pyrimidinov\u00FDch dimer\u016F a purinov\u00FDch trimer\u016F jako analog\u016F Watson-Crickov\u00FDch p\u00E1r\u016F b\u00E1z\u00ED a Hoogsteenov\u00FDch triplet\u016F" . . . "Neuvedeno."@en . "The aim of the project is the synthesis of several novel types of analogues of Watson-Crick base pairs and Hoogsteen triplets. Biaryl-type directly bound purine-purine and purine-pyrimidine dimers will be the first type of analogues planned. Other proposed analogues will contain a linker between the two bases of varying length, configuration and conformation flexibility (e.g. ethynylidene, cis/transetenylidene, o-/p-phenylene etc.). Besides that we plan to prepare 'trimers' containing three purinemoieties and a central benzene or triazine unit. 6-Alkynylpurines, key intermediates in the synthesis, will be also used for the preparation of conjugates of purines with quinoid-type redox systems. The target compounds will not only be submitted to biological activity screening (antitumor and antiviral activity), but also their most important properties will be studied, e.g. atropisomerism and axial chirality of the biary-type compounds etc. The results should, besides the determination of"@en . "14"^^ . . . "14"^^ . "Hlavn\u00ED c\u00EDle projektu byly spln\u011Bny. Byly vypracov\u00E1ny postupy p\u0159\u00EDpravy nov\u00FDch typ\u016F kovalentn\u011B v\u00E1zan\u00FDch analog\u016F nukleob\u00E1z\u00ED. V\u011Bt\u0161ina p\u0159ipraven\u00FDch l\u00E1tek byla testov\u00E1na na cytostatickou aktivitu a u l\u00E1tek bis(purin-6-yl)acetylen\u016F a diacetylen\u016F byla nalezena v\u00FD"@cs . . . . . . . . "GA203/00/0036" . "1"^^ . "2008-05-19+02:00"^^ . "1"^^ . . "Synthesis of purine-purine and purine-pyrimidine dimers and purine trimers as analogues of Watson-Crick base pairs and Hoogsteen triplets"@en . "http://www.isvav.cz/projectDetail.do?rowId=GA203/00/0036"^^ . . . "0"^^ . . .