"Applications of statistic treatment of Raman scattering signal in study of interactions of porfyrin derivatives with biological structures"@en . "4"^^ . "0"^^ . "4"^^ . "1"^^ . "Aplikace statistick\u00E9ho zpracov\u00E1n\u00ED sign\u00E1lu Ramanova rozptylu p\u0159i studiu interakc\u00ED porfyrinov\u00FDch deriv\u00E1t\u016F s biologick\u00FDmi strukturami" . . "The project has been proposed as an application of methodological results obtained during statistical noise analysis in Raman scattering studied in non-homogenous aqueous samples. The aim of this project is investigation of the formation, structure and dynamics properties of the complexes of the new syntetized derivatives of porphyrins, efficient fotosenzibilizators in photodynamics therapy of cancer, with nucleic acids and phospholipidic membranes. Extremely low concentration corresponding to the physiological conditions will be studied due to employment of very sensitive surface-enhanced Raman scattering (SERS) technique."@en . . . . . . . . . "http://www.isvav.cz/projectDetail.do?rowId=GA202/98/P139"^^ . . "GA202/98/P139" . . . . . "Odborn\u00FDm p\u0159\u00EDnosem projektu je spojen\u00ED \u0161pi\u010Dkov\u00E9 metodiky studia povrchem zas\u00EDlen\u00E9ho Ramanova rozptylu, pokro\u010Dil\u00FDch matematick\u00FDch metod p\u0159i statistick\u00E9m zpracov\u00E1n\u00ED dat a aplikac\u00ED na slo\u017Eit\u00E9 organick\u00E9 molekuly s biologick\u00FDm kontextem. Byla vypracov\u00E1na metod"@cs . "Projekt je navr\u017Een jako konkr\u00E9tn\u00ED aplikace metodick\u00FDch v\u00FDsledk\u016F dosa\u017Een\u00FDch p\u0159i rozvoji metod statistick\u00E9ho zpracov\u00E1n\u00ED \u0161umu v Ramanov\u011B rozptylu nehomogenn\u00EDch kapaln\u00FDch vzork\u016F v r\u00E1mci navazuj\u00EDc\u00EDho projektu GA \u010CR. C\u00EDlem je sledov\u00E1n\u00ED tvorby a strukturn\u00EDch adynamick\u00FDch vlastnost\u00ED komplex\u016F nov\u011B systematizovan\u00FDch porfyrinov\u00FDch deriv\u00E1t\u016F, potenci\u00E1ln\u00EDch fotosenzibiliz\u00E1tor\u016F pro fotodynamickou terapii, s nukleov\u00FDmi kyselinami a fosfolipidov\u00FDmi membr\u00E1nami. D\u00EDky vyu\u017Eit\u00ED techniky povrchem zes\u00EDlen\u00E9ho Tamanova rozptyl u v koloidech st\u0159\u00EDbra p\u0159ipraven\u00FDch laserovou ablac\u00ED bude mo\u017En\u00E9 dosa\u017Een\u00E9 v\u00FDsledky vzt\u00E1hnout k extr\u00E9mn\u011B n\u00EDzk\u00FDm koncentrac\u00EDm odpov\u00EDdaj\u00EDc\u00EDm situaci v \u017Eiv\u00E9 tk\u00E1ni p\u0159i klinick\u00E9 aplikaci." . . "0"^^ .