"The aim of the proposed project is to develop fundamental understanding of the mutual interaction of two successive shock waves focused to a common focal point - focused tandem shock waves (FTWS), their physical and chemical effects and their interactions with biological objects focused on the possible application of FTWS for cancer treatment and controlled drug delivery. For FTWS generation a novel type of generator will be used with ability to produce with adjustable delay two successive cylindrical pressure waves generated by underwater multichannel electrical discharge at a %22composite%22 anode that are focused by a metallic parabolic reflector (cathode) and transformed into a strong shock wave. We expect that collapsing cavitations created by the second wave in evolution of cavitations produced by the first wave create secondary, short wavelength shocks that can be able to interact with cell scale structures. We suppose that by this way it could be possible to increase efficiency of chemotherapy treatment of cancers. These assumptions will be tested on cell suspensions, soft animal tissues, including cancer tissues and with liposomes and ex vivo and in vivo experiments on laboratory animals."@en . "2011-12-31+01:00"^^ . "elektrick\u00E9 v\u00FDboje ve vod\u011B, fokusovan\u00E9 r\u00E1zov\u00E9 vlny, kavitace, n\u00E1dorov\u00E9 bu\u0148ky, lipozomy"@en . . "http://www.isvav.cz/projectDetail.do?rowId=GA202/09/1151"^^ . . . "Dv\u011B po sob\u011B n\u00E1sleduj\u00EDc\u00ED fokusovan\u00E9 r\u00E1zov\u00E9 vlny a jejich potenci\u00E1ln\u00ED vyu\u017Eit\u00ED v terapii n\u00E1dor\u016F a \u0159\u00EDzen\u00E9m uvol\u0148ov\u00E1n\u00ED l\u00E9\u010Div" . "GA202/09/1151" . "V\u00FDzkum vz\u00E1jemn\u00E9 interakce dvou po sob\u011B n\u00E1sleduj\u00EDc\u00EDch r\u00E1zov\u00FDch vln fokusovan\u00FDch do spole\u010Dn\u00E9ho ohniska. V\u00FDzkum interakce r\u00E1zov\u00FDch vln s m\u011Bkk\u00FDmi tk\u00E1n\u011Bmi laboratorn\u00EDch zv\u00ED\u0159at, v\u010Detn\u011B tk\u00E1n\u00ED n\u00E1dorov\u00FDch. V\u00FDzkum \u00FA\u010Dinku r\u00E1zov\u00FDch vln a kombinovan\u00E9ho \u00FA\u010Dinku r\u00E1zov\u00FDch vln a chemoterapie na r\u016Fst n\u00E1dor\u016F." . "elektrick\u00E9 v\u00FDboje ve vod\u011B" . "Focused tandem shock waves and their potential application in cancer treatment and controlled drug delivery"@en . . "1"^^ . . "2"^^ . "2015-03-02+01:00"^^ . . "0"^^ . . "2009-01-01+01:00"^^ . " n\u00E1dorov\u00E9 bu\u0148ky" . . " kavitace" . . . . . . . "The project was excellent, both in terms of expertise and in terms of disbursement of funds."@en . "\u0158e\u0161en\u00ED projektu prob\u011Bhlo v\u00FDte\u010Dn\u011B, jak z hlediska odborn\u00E9ho tak i z hlediska \u010Derp\u00E1n\u00ED finan\u010Dn\u00EDch prost\u0159edk\u016F."@cs . . "2011-04-16+02:00"^^ . . . "28"^^ . "28"^^ . " fokusovan\u00E9 r\u00E1zov\u00E9 vlny" . . .