. "2006-01-01+01:00"^^ . "2008-04-25+02:00"^^ . . "bioinformatics; DNA; nanostructures; formal automaton"@en . "1"^^ . "2009-10-22+02:00"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA201/06/0567"^^ . "The project was focused on research in the areas of biocomputing, bioinformatics and their contact points. This implied the presence of experts from both these fields in the project team. The biocomputing research was thematically oriented at DNA computi"@en . "0"^^ . . . "0"^^ . " DNA" . "Tematikou grantov\u00E9ho projektu byl v\u00FDzkum v oborech biov\u00FDpo\u010Dt\u016F, bioinformatiky a jejich vz\u00E1jemn\u00FDch sty\u010Dn\u00FDch bod\u016F. Z toho d\u016Fvodu \u0159e\u0161itelsk\u00FD t\u00FDm zahrnoval experty obou t\u011Bchto p\u0159\u00EDbuzn\u00FDch obor\u016F. Tematicky byl v\u00FDzkum v oblasti biov\u00FDpo\u010Dt\u016F zam\u011B\u0159en zejm\u00E9na na DNA"@cs . "2008-12-31+01:00"^^ . . " nanostructures" . "The\u00A0project focuses on study of mathematical and computational properties of DNA (or also other organic molecules),\u00A0with mutual\u00A0interactions\u00A0of bioinformatics and biocomputing techniques. Particularly, we propose:\u00A0to develop further the research of regularity and order in DNA sequences and also other polymer molecules, and to characterize these properties mathematically, to study mathematical description of self-assembly nanostructures composed from (organic) polymer molecules, with possible nanotechnology applications,to study and model mathematical and computational aspects of mutual bonds within and between DNA, RNA and protein molecules; to investigate further related topics, as computational aspects of evolution with a special focus on DNA, or information aspects of cellular processes. Examples of possible applications of the above mentioned theoretical research: An increase of electrophoresis through put applicable in forensic and medical genetics. Modeling of DNA degradation and"@en . "16"^^ . . . . . "16"^^ . . . "C\u00EDlem projektu je v\u00FDzkum matematick\u00FDch a informa\u010Dn\u00EDch vlastnost\u00ED molekul DNA (p\u0159\u00EDp. i dal\u0161\u00EDch organick\u00FDch molekul), s vyu\u017Eit\u00EDm mezioborov\u00E9 spolupr\u00E1ce bioinformatiky a biov\u00FDpo\u010Dt\u016F. Konkr\u00E9tn\u011B navrhujeme:\u00A0rozv\u00EDjen\u00ED v\u00FDzkumu pravidelnost\u00ED a uspo\u0159\u00E1danosti v\u00A0sekvenc\u00EDch DNA i jin\u00FDch polymeruj\u00EDc\u00EDch molekul, a jejich matematickou charakterizaci, studium matematick\u00E9ho popisu samosestavuj\u00EDc\u00EDch se struktur slo\u017Een\u00FDch z\u00A0 (organick\u00FDch) polymeruj\u00EDc\u00EDch molekul, a mo\u017En\u00E9 aplikace takov\u00FDch struktur, studium a modelov\u00E1n\u00EDmatematick\u00FDch a informa\u010Dn\u00EDch aspekt\u016F vz\u00E1jemn\u00FDch vazeb mezi molekulami DNA, RNA a p\u0159\u00EDpadn\u011B protein\u016F,dal\u0161\u00ED souvisej\u00EDc\u00ED okrajov\u00E1 t\u00E9mata, nap\u0159\u00EDklad v\u00FDpo\u010Detn\u00ED aspekty evoluce se zam\u011B\u0159en\u00EDm na jej\u00ED projevy v\u00A0DNA, nebo informa\u010Dn\u00EDch aspekty bun\u011B\u010Dn\u00FDch proces\u016F. P\u0159\u00EDklady mo\u017En\u00FDch aplikac\u00ED v\u00FD\u0161e popsan\u00E9ho teoretick\u00E9ho v\u00FDzkumu:\u00A0Zv\u00FD\u0161en\u00ED propustnosti elektrofor\u00E9zy s vyu\u017Eit\u00EDm ve\u00A0forenzn\u00ED a l\u00E9ka\u0159sk\u00E9 genetice. Modelov\u00E1n\u00ED degradace DNA a\u00A0amplifikace degradovan\u00E9 DNA pomoc\u00ED PCR, s vyu\u017Eit\u00EDm nap\u0159. v\u00A0genotypizaci DNA z" . . "Bioinformatika a biov\u00FDpo\u010Dty: souvislosti, modely a aplikace" . . "GA201/06/0567" . . . . "Bioinformatics and biocomputing: connections, models and applications"@en . . . "bioinformatics" .