. "tick-borne encephalitis virus" . "http://www.isvav.cz/projectDetail.do?rowId=GA14-29256S"^^ . . "Mechanisms of neuronal injury during tick-borne encephalitis virus infection of the CNS."@en . "2014-02-21+01:00"^^ . "0"^^ . . . "3"^^ . . "2014-01-01+01:00"^^ . "0"^^ . "3"^^ . . . " neuroinfection" . . "1"^^ . . "2016-12-31+01:00"^^ . . . . . "GA14-29256S" . . "2015-04-23+02:00"^^ . "Tick-borne encephalitis (TBE), a disease caused by tick-borne encephalitis virus (TBEV), represents one of the most important and serious neuroinfections in Europe and North-eastern Asia. Despite the medical importance of this disease, some crucial steps in the development of encephalitis remain poorly understood. In particular, the mechanisms of TBEV-induced injury to the central nervous system (CNS) are unclear. Here we propose a new project to study interactions of TBEV with primary human neurons, mechanisms of their injury and antiviral defence, as well as the interaction of the infected neurons with other key cells in the CNS (astrocytes, pericytes, microglia and brain microvascular epithelial cells). We propose that the innate immune response is an important cause of neuron death during the acute infection. This is in contrast to the prevailing hypothesis that neuron loss is mediated solely by virus. The results of this project should provide new crucial data about the neuropathogenesis of TBE."@en . "tick-borne encephalitis virus, tick-borne encephalitis, neuroinfection, neurons"@en . "Mechanismy po\u0161kozen\u00ED neuron\u016F p\u0159i infekci virem kl\u00ED\u0161\u0165ov\u00E9 encefalitidy v CNS" . . "Kl\u00ED\u0161\u0165ov\u00E1 encefalitida (KE), onemocn\u011Bn\u00ED zp\u016Fsoben\u00E9 virem KE, p\u0159edstavuje jednu z nejz\u00E1va\u017En\u011Bj\u0161\u00EDch neuroinfekc\u00ED vyskytuj\u00EDc\u00EDch se v Evrop\u011B a severov\u00FDchodn\u00ED Asii. Navzdory medic\u00EDnsk\u00E9mu v\u00FDznamu tohoto onemocn\u011Bn\u00ED ale z\u016Fst\u00E1v\u00E1 \u0159ada ot\u00E1zek t\u00FDkaj\u00EDc\u00EDch se rozvoje encefalitidy st\u00E1le nezodpov\u011Bzen\u00FDch. P\u0159edev\u0161\u00EDm mechanismy po\u0161kozen\u00ED neuron\u016F p\u0159i infekci virem KE jsou kompletn\u011B neprozkouman\u00E9. Navrhovan\u00FD projekt je zam\u011B\u0159en na studium interakc\u00ED viru KE s prim\u00E1rn\u00EDmi lidsk\u00FDmi neurony, mechanism\u016F jejich po\u0161kozen\u00ED a antivirov\u00E9 obrany a d\u00E1le na interakci infikovan\u00FDch neuron\u016F s dal\u0161\u00EDmi kl\u00ED\u010Dov\u00FDmi bu\u0148kami centr\u00E1ln\u00ED nervov\u00E9 soustavy (astrocyty, pericyty, mikroglie a mikrovaskul\u00E1rn\u00ED endoteli\u00E1ln\u00ED bu\u0148ky mozku). Na z\u00E1kladn\u011B na\u0161ich p\u0159edb\u011B\u017En\u00FDch dat se zd\u00E1, \u017Ee p\u0159irozen\u00E1 imunitn\u00ED odezva hraje zcela z\u00E1sadn\u00ED roli v po\u0161kozen\u00ED neuron\u016F p\u0159i infekci, co\u017E je v rozporu s p\u0159evl\u00E1daj\u00EDc\u00ED hypot\u00E9zou, \u017Ee po\u0161kozen\u00ED neuron\u016F p\u0159i KE je d\u00E1no prim\u00E1rn\u011B samotou virovou replikac\u00ED. V\u00FDsledky tohoto projektu by m\u011Bly velmi v\u00FDraznou m\u011Brou napomoci pozn\u00E1n\u00ED mechanism\u016F neuropatogeneze tohoto v\u00FDznamn\u00E9ho onemocn\u011Bn\u00ED." . " tick-borne encephalitis" . . .