. "http://www.isvav.cz/projectDetail.do?rowId=GA14-21903S"^^ . . . " genetic component" . "2014-02-25+01:00"^^ . " CNV analysis" . . "0"^^ . " mutation" . . "1"^^ . . . . . "1"^^ . "Studium genetick\u00E9 architektury impulsivn\u00EDho n\u00E1siln\u00E9ho chov\u00E1n\u00ED" . "0"^^ . "1"^^ . "Violent behavior is fascinating biological and sociological phenomena. It results from interactions between multiple genetic, biological, environmental and sociological factors. Knowledge on individual genetic determinants is sparse. We plan therefore to investigate within next three years ~ 350 impulsively violent male offenders assessed using MINI diagnostic interview, Hare Psychopathy Checklist, Eysenck IVE test and Tridimensional Personality Questionnaire. In DNA of these individuals we will, using genome-wide copy-number analysis, exome sequencing, targeted resequencing and aggregate testing, search for individual genes or groups of genes involved in selected metabolic and regulatory pathways that are showing statistically significantly different occurrence of rare coding variants compare to general population. Evaluation of such defined genes and variants should identify spectrum of high-risk violence genes and increase our knowledge of genetic determinants of impulsive violence."@en . " rare variant" . " exome sequencing" . "GA14-21903S" . . . "2015-04-23+02:00"^^ . . " association analysis" . . " complex trait" . "Impulsivn\u00ED n\u00E1siln\u00E9 chov\u00E1n\u00ED p\u0159edstavuje z\u00E1va\u017En\u00FD spole\u010Densk\u00FD probl\u00E9m a fascinuj\u00EDc\u00ED biologick\u00FD fenom\u00E9n. Je v\u00FDsledkem komplexn\u00EDch interakc\u00ED \u0159ady genetick\u00FDch, biologick\u00FDch a soci\u00E1ln\u00EDch faktor\u016F a jeho genetick\u00E1 komponenta je m\u00E1lo zn\u00E1ma. B\u011Bhem t\u0159\u00ED let proto pl\u00E1nujeme zkoumat ~ 350 mu\u017E\u016F odsouzen\u00FDch pro opakovan\u00E9 n\u00E1siln\u00E9 \u010Diny spojen\u00E9 s v\u00FDraznou impulsivitou definovanou pomoc\u00ED M.I.N.I. dotazn\u00EDku, Eysenckova IVE testu, Hareova dotazn\u00EDku psychopatie a Cloningerova dotazn\u00EDku temperamentu. V DNA t\u011Bchto mu\u017E\u016F budeme pomoc\u00ED anal\u00FDzy zm\u011Bn po\u010Dtu kopi\u00ED DNA, exomov\u00E9ho sekvenov\u00E1n\u00ED, c\u00EDlen\u00E9ho resekvenov\u00E1n\u00ED a agregativn\u00EDch test\u016F vyhled\u00E1vat jednotliv\u00E9 geny p\u0159\u00EDpadn\u011B skupiny gen\u016F vybran\u00FDch metabolick\u00FDch \u010Di regula\u010Dn\u00EDch drah, kter\u00E9 vykazuj\u00ED u studovan\u00FDch osob oproti b\u011B\u017En\u00E9 populaci statisticky v\u00FDznamn\u011B odli\u0161n\u00FD v\u00FDskyt vz\u00E1cn\u00FDch funk\u010Dn\u011B v\u00FDznamn\u00FDch alelick\u00FDch variant. Zhodnocen\u00ED funkce takto ur\u010Den\u00FDch gen\u016F a interpretace efektu nalezen\u00FDch vz\u00E1cn\u00FDch alelick\u00FDch variant by m\u011Bly v\u00E9st k definici souboru gen\u016F \u2013 genetick\u00E9 architektury \u2013 impulsivn\u00EDho n\u00E1siln\u00E9ho chov\u00E1n\u00ED a lep\u0161\u00EDmu porozum\u011Bn\u00ED jeho molekul\u00E1rn\u00ED a biologick\u00E9 podstaty." . . "2016-12-31+01:00"^^ . . "impulsive violence, complex trait, genetic component, exome sequencing, CNV analysis, mutation, rare variant, association analysis, aggregate tests"@en . . . "2014-01-01+01:00"^^ . "Genetic architecture of impulsive violence"@en . "impulsive violence" .