"Anti-stresov\u00E9 reakce reguluj\u00EDc\u00ED metabolickou homeost\u00E1zu u hmyzu" . . . " receptor" . " oxidative stress" . "2016-12-31+01:00"^^ . . "The proposed project is focused on a functional study of adipokinetic hormone (AKH) and its possible links or parallels with the adenosine (Ade) signalling pathway. The work will utilize two insect models - Pyrrhocoris apterus and Drosophila melanogaster. P. apterus will serve as a classical physiological model for elucidation of AKH and Ade role in insect body, while D. melanogaster with its easily available mutants will serve as a powerful genetic model to delineate the precise pathways employed. The project will study crucial aspects of AKH and Ade signalling in (1) anti-stress reactions elicited by stressor applications (paraquat, insecticides) with the emphasis on elucidation of role of AKH in the response at the (sub)cellular level, and (2) in physiological processes affecting homeostasis as in oxidative stress responses, digestion and locomotion. The results might potentially help in the development of novel methods of insect pest control, and in elucidation of crucial aspects of the physiological effects of Ade and neuropeptide signalling in mammals including human beings."@en . . "http://www.isvav.cz/projectDetail.do?rowId=GA14-07172S"^^ . " locomotion" . . "P\u0159edkl\u00E1dan\u00FD projekt se zab\u00FDv\u00E1 studiem funkc\u00ED adipokinetick\u00E9ho hormonu (AKH) a jeho mo\u017En\u00FDm vztahem nebo paralelou s adenosinovou sign\u00E1ln\u00ED dr\u00E1hou. Pro pr\u00E1ci na projektu budou pou\u017Eity dva modely \u2013 plo\u0161tice Pyrrhocoris apterus a moucha Drosophila melanogaster. Plo\u0161tice P. apterus bude slou\u017Eit ke studiu funkc\u00ED AKH a adenosinu v t\u011Ble hmyzu jako klasick\u00FD fyziologick\u00FD model, kde\u017Eto mutanti Drosophila budou slou\u017Eit ke studiu t\u011Bchto funkc\u00ED jako genetick\u00FD model. Projekt bude studovat z\u00E1sadn\u00ED aspekty signalizace AKH a adenosinu v (1) procesech, kter\u00E9 jsou spu\u0161t\u011Bny aplikac\u00ED stresor\u016F (paraquat, insekticidy) a (2) procesech ovliv\u0148uj\u00EDc\u00EDch homeost\u00E1zu jako je oxida\u010Dn\u00ED metabolismus, tr\u00E1ven\u00ED a lokomoce. D\u016Fraz bude kladen na objasn\u011Bn\u00ED sign\u00E1ln\u00ED \u00FAlohy AKH ve spu\u0161t\u011Bn\u00ED anti-stresov\u00E9 kask\u00E1dy reakc\u00ED na (sub)bun\u011B\u010Dn\u00E9 \u00FArovni. Z\u00EDskan\u00E9 v\u00FDsledky by v budoucnu mohly b\u00FDt vyu\u017Eity k v\u00FDvoji nov\u00FDch metod kontroly hmyz\u00EDch \u0161k\u016Fdc\u016F, tak\u00E9 by v\u0161ak mohly p\u0159isp\u011Bt k vysv\u011Btlen\u00ED fyziologick\u00E9ho v\u00FDznamu adenosinov\u00E9 i neurohormon\u00E1ln\u00ED signalizaci u savc\u016F v\u010Detn\u011B \u010Dlov\u011Bka." . " adipokinetic hormone" . "2014-01-01+01:00"^^ . . " adenosine" . . . "stress, oxidative stress, signalling pathway, homeostasis, adipokinetic hormone, adenosine, receptor, locomotion, digestion"@en . . "0"^^ . "GA14-07172S" . "2"^^ . "Anti-stress reactions regulating metabolic homeostasis in insects"@en . "0"^^ . . "2015-04-23+02:00"^^ . . "2"^^ . "1"^^ . . . " homeostasis" . . "stress" . . . " signalling pathway" . "2014-03-14+01:00"^^ . .