"GA13-24983S" . "1"^^ . "2013-02-01+01:00"^^ . "2"^^ . . "eukaryotes" . . . "Unravelling the early evolution of the eukaryotic cell through exploring the genomes of the eukaryotic superphylum Discoba"@en . " genomics" . "0"^^ . . . "2014-05-16+02:00"^^ . . . . " Malawimonadida" . . " phylogeny" . . "9"^^ . "2016-12-31+01:00"^^ . "9"^^ . "Odhalov\u00E1n\u00ED \u010Dasn\u00E9 evoluce eukaryotick\u00E9 bu\u0148ky pr\u016Fzkumem genom\u016F eukaryotick\u00E9ho nadkmene Discoba" . . . . " Discoba" . " evolution" . " Excavata" . . . "http://www.isvav.cz/projectDetail.do?rowId=GA13-24983S"^^ . "Eukaryotes have evolved an enormous diversity of cellular organization and its molecular underpinnings. However, many fundamental aspects concerning the early evolutionary history eukaryotes and their cells still remain murky. Discoba is a recently defined superphylum embracing diverse unicellular eukaryotes (protists) with potentially primitive cellular and genomic features; some hypotheses even place the root of the eukaryote phylogeny into the Discoba. However, better understanding of the position and role of the Discoba in eukaryote evolution is hampered by a very limited and highly biased sampling of discoban genome sequences. We therefore propose a project to sequence, annotate, and analyse the genomes of several discobans and of a representative of the enigmatic eukaryotic lineage Malawimonadida exhibiting morphological affinities to Discoba. The genomic resources generated by the project will be explored in a comparative framework to illuminate the biology of the sequenced organisms and, particularly, to answer central questions of early eukaryote evolution and phylogeny."@en . . "2015-04-23+02:00"^^ . "eukaryotes; evolution; phylogeny; Discoba; Malawimonadida; Excavata; genomics; mitochondrion"@en . . "Eukaryota se vyvinula do obrovsk\u00E9 rozmanitosti na \u00FArovni bun\u011B\u010Dn\u00E9 organizace i jej\u00EDch molekul\u00E1rn\u00EDch z\u00E1klad\u016F. Mnoho z\u00E1sadn\u00EDch aspekt\u016F \u010Dasn\u00E9 evolu\u010Dn\u00ED historie eukaryot a jejich bun\u011Bk v\u0161ak st\u00E1le z\u016Fst\u00E1v\u00E1 nejasn\u00FDch. Discoba jsou ned\u00E1vno ustanoven\u00FDm nadkmenem zahrnuj\u00EDc\u00EDm rozmanit\u00E1 jednobun\u011B\u010Dn\u00E1 eukaryota (protista) s potenci\u00E1ln\u011B primitivn\u00EDmi bun\u011B\u010Dn\u00FDmi a genomov\u00FDmi znaky; n\u011Bkter\u00E9 hypot\u00E9zy dokonce p\u0159edpokl\u00E1daj\u00ED, \u017Ee ko\u0159en eukaryotick\u00E9 fylogeneze le\u017E\u00ED pr\u00E1v\u011B ve skupin\u011B Discoba. P\u0159esn\u011Bj\u0161\u00EDmu pochopen\u00ED pozice a role diskob\u016F v evoluci eukaryot br\u00E1n\u00ED velmi omezen\u00FD a nerovnom\u011Brn\u00FD sampling genomov\u00FDch sekvenc\u00ED diskob\u016F. Proto navrhujeme projekt sekvenov\u00E1n\u00ED, anotace a anal\u00FDzy genom\u016F n\u011Bkolika diskob\u016F a jednoho z\u00E1stupce z\u00E1hadn\u00E9 eukaryotick\u00E9 linie Malawimonadida morfologicky podobn\u00E9 diskob\u016Fm. Z\u00EDskan\u00E1 genomov\u00E1 data budou prozkoum\u00E1na postupy srovn\u00E1vac\u00ED genomiky s c\u00EDlem osv\u011Btlit biologii sekvenovan\u00FDch organism\u016F a p\u0159edev\u0161\u00EDm zodpov\u011Bd\u011Bt \u00FAst\u0159edn\u00ED ot\u00E1zky \u010Dasn\u00E9 evoluce a fylogeneze eukaryot." .