. . "L\u00E9\u010Dba obezity a metabolick\u00E9ho syndromu vy\u017Eaduje zm\u011Bnu \u017Eivotn\u00EDho stylu. V pokusech na my\u0161\u00EDch krmen\u00FDch dietou s vysok\u00FDm obsahem kuku\u0159i\u010Dn\u00E9ho oleje jsme ned\u00E1vno prok\u00E1zali aditivn\u00ED p\u016Fsoben\u00ED m\u00EDrn\u00E9 kalorick\u00E9 restrikce (10%; CR) a substituce 9% tuk\u016F v potrav\u011B za n-3 mastn\u00E9 kyseliny s dlouh\u00FDm \u0159et\u011Bzcem (EPA a DHA), kter\u00E9 se projevilo v prevenci obezity a doprovodn\u00FDch metabolick\u00FDch poruch. Aditivn\u00ED \u00FA\u010Dinky byly doprov\u00E1zeny zv\u00FD\u0161en\u00EDm oxidace mastn\u00FDch kyselin, relativn\u011B specificky v abdomin\u00E1ln\u00ED tukov\u00E9 tk\u00E1ni (TK). Metabolick\u00E9 zm\u011Bny v TK pravd\u011Bpodobn\u011B souvisely se synergickou stimulac\u00ED tvorby lipidov\u00FDch protiz\u00E1n\u011Btliv\u00FDch medi\u00E1tor\u016F . V projektu se zam\u011B\u0159\u00EDme na charakterizaci 1) z\u00E1vislosti efekt\u016F CR+EPA/DHA na obsahu cukr\u016F v diet\u011B ; 2) biochemickou podstatu energetick\u00E9ho v\u00FDdeje stimulovan\u00E9ho v TK vlivem CR+EPA/DHA; 3) integruj\u00EDc\u00ED \u00FAlohu lipidov\u00FDch medi\u00E1tor\u016F a PPARg ve vlivech CR+EPA/DHA na z\u00E1n\u011Bt a metabolizmus; a 4) kombinovan\u00E9 p\u016Fsoben\u00ED mimetika CR resveratrolu a EPA/DHA. V\u00FDsledky napomohou v l\u00E9\u010Db\u011B obezity s vyu\u017Eit\u00EDm kombinace nefarmakologick\u00FDch p\u0159\u00EDstup\u016F zalo\u017Een\u00FDch na diet\u011B." . . " insulin resistance" . . . "2017-12-31+01:00"^^ . "2013-02-01+01:00"^^ . " chronic low grate inflammation" . " calorie restriction" . . . . . . " lipid metabolism" . "2014-03-31+02:00"^^ . . "Omega 3, calorie restriction, obesity, insulin resistance, adipose tissue, chronic low grate inflammation, lipid metabolism, energy metabolism"@en . . "Zv\u00FD\u0161en\u00ED energetick\u00E9ho v\u00FDdeje v tukov\u00E9 tk\u00E1ni kombinovan\u00FDm p\u016Fsoben\u00EDm n-3 mastn\u00FDch kyselin, resveratrolu a kalorick\u00E9 restrikce" . . . . "3"^^ . "0"^^ . "Enhancing energy expenditure in white adipose tissue by combination treatments using n-3 fatty acids, resveratrol and calorie restriction"@en . "GA13-00871S" . "3"^^ . "1"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA13-00871S"^^ . . . "0"^^ . "Lifestyle changes are necessary for counteraction of obesity and metabolic syndrome. We have demonstrated recently in mice that combination treatment with 10%-calorie restriction (CR) and 9%-replacement of lipids in corn oil-based high-fat diet by long-chain n-3 fatty acids (EPA and DHA) exerted additive effects in the prevention of obesity and preservation of metabolic health, while inducing mitochondrial fatty acid oxidation, quite specifically in abdominal white fat (WAT). Metabolic changes in WAT were associated with synergistic up-regulation of anti-inflammatory lipid mediators by CR+EPA/DHA treatment. We aim to characterize 1) role of dietary carbohydrates in the effects of the treatment; 2) the biochemical basis of energy expenditure induced in WAT by the treatment; 3) the integrating role of lipid mediators and PPARg in the effects of the treatment on inflammation and metabolism; and 4) the effects of a combined use of a natural CR mimetic resveratrol and EPA/DHA. Our results will help to improve obesity management by combined use of non-pharmacological dietary approaches."@en . "Omega 3" . " obesity" . "2015-04-23+02:00"^^ . " adipose tissue" .