" polycycloolefin" . . "http://www.isvav.cz/projectDetail.do?rowId=GA106/06/0761"^^ . . "The submitted project is concerned with proposal and testing of an active hybrid composite in which the reinforcement will be formed by polycycloolefin macro-lattices (or Ti-Ni wires encased in COC polymer) and the matrix will be formed in phase I (pre-operational) by a biologically inactive component, i.e. collagen I, proteoglycans and growth factors and, in phase II (post-operational), following intergrowth (%22migration%22) of cells into the %22body%22 of the composite replacement, by natural biomaterial. The surface of the COC lattices will be subjected to plasmatic surface modification and then they will be saturated with collagen-proteoglycan copolymer. In order that this copolymer be as resistant as possible to hydrolytic enzymes, the highly cross-linked collagen fraction ISC40 will be used. The lattices must be constructed so as to permit diffusion of nutrients and oxygen to the entire depth of the tissue and simultaneously also growth of the connective cells into the implant. The"@en . . "GA106/06/0761" . . "1"^^ . . "3"^^ . . "P\u0159edlo\u017Een\u00FD projekt je zam\u011B\u0159en na n\u00E1vrh a na ov\u011B\u0159en\u00ED aktivn\u00EDho hybridn\u00EDho kompozitu, v\u00A0n\u011Bm\u017E armov\u00E1n\u00ED bude tvo\u0159eno makrom\u0159\u00ED\u017Ekami z\u00A0polycykloolef\u00EDn\u016F (event. Ti-Ni dr\u00E1tky obalen\u00FDmi polymerem COC) a matrice bude tvo\u0159ena v\u00A0I. f\u00E1zi (preopera\u010Dn\u00ED)\u00A0 biologicky neaktivn\u00ED komponentou, tj. kolagenem I., proteoglykany, r\u016Fstov\u00FDmi faktory a ve II. f\u00E1zi (poopera\u010Dn\u00ED), \u00A0po vr\u016Fstu (%22vcestov\u00E1n\u00ED%22) bun\u011Bk do %22t\u011Bla%22 kompozitn\u00ED n\u00E1hrady, p\u0159irozen\u00FDm\u00A0 biomateri\u00E1lem. M\u0159\u00ED\u017Eky COC budou plasmaticky povrchov\u011B modifikov\u00E1ny a pot\u00E9 nasyceny kopolymerem kolagen-proteoglykany. Aby uva\u017Eovan\u00FD kopolymer byl co nejodoln\u011Bj\u0161\u00ED vzhledem k\u00A0 hydrolytick\u00FDm enzym\u016Fm, bude pou\u017Eita hodn\u011B se\u0159et\u011Bzen\u00E1 kolagenn\u00ED frakce ISC40. M\u0159\u00ED\u017Eky\u00A0 mus\u00ED b\u00FDt konstruov\u00E1ny tak, aby umo\u017Enily difuzi \u017Eivin a kysl\u00EDku do cel\u00E9 hloubky tk\u00E1n\u011B a z\u00E1rove\u0148 tak\u00E9 vr\u016Fst\u00E1n\u00ED pojivov\u00FDch bun\u011Bk do implant\u00E1tu. Zpo\u010D\u00E1tku neaktivn\u00ED materi\u00E1l biologick\u00E9ho p\u016Fvodu (tj. kolagen a proteoglykany) se po vcestov\u00E1n\u00ED p\u0159\u00EDslu\u0161n\u00FDch bun\u011Bk do jeho prost\u0159ed\u00ED bude p\u0159em\u011B\u0148ovat\u00A0 a\u00A0transformovat\u00A0 do tk\u00E1n\u011B" . "composite; biocomposite; polycycloolefin; surface modification; collagen"@en . " surface modification" . "Hybridn\u00ED biokompozit nov\u00E9 generace" . . "0"^^ . "2006-01-01+01:00"^^ . . "Presented grant project has been aimend on the design, development and on clinical verifications of biologically active replacements supporting the creation of new articular cartilage and subchondral bone. The low component of replacement has been create"@en . "composite" . "2009-10-22+02:00"^^ . . "Hybrid Biocomposite of a New Generation"@en . . "2008-12-31+01:00"^^ . . "Grantov\u00FD projekt byl zam\u011B\u0159en na n\u00E1vrh, v\u00FDvoj a na klinick\u00E9 ov\u011B\u0159en\u00ED biologicky aktivn\u00ED n\u00E1hrady (BAHC)i, podporuj\u00EDc\u00ED vznik nov\u00E9 artikul\u00E1rn\u00ED chrupavky. Origin\u00E1ln\u00ED n\u00E1hrada subchondr\u00E1ln\u00ED kosti a artikul\u00E1rn\u00ED chrupavky se skl\u00E1d\u00E1 z doln\u00ED komponenty (cykloolefin:"@cs . . " biocomposite" . "31"^^ . . . "31"^^ . . . . . . "2008-04-25+02:00"^^ . .