. "C\u00EDle grantov\u00E9ho projektu byly zam\u011B\u0159eny na problematiku \u0159\u00EDzen\u00ED integrace \u017Eiv\u00E9 tk\u00E1n\u011B s polymern\u00EDm materi\u00E1lem. Vytvo\u0159en\u00EDm fyzik\u00E1ln\u00EDch vazeb na rozhran\u00ED kolagenu s \u00A0polymerovou matric\u00ED a vznikem vazivov\u00E9ho vazebn\u00EDho pole s\u00A0kortikalis, byl prok\u00E1z\u00E1n nov\u00FD p\u0159\u00EDst"@cs . . . "23"^^ . . "Neuvedeno."@en . "Control of bioadhesion of connective tissue to the polymer composites"@en . "23"^^ . "0"^^ . . "http://www.isvav.cz/projectDetail.do?rowId=GA106/03/0255"^^ . "2009-01-15+01:00"^^ . "GA106/03/0255" . . "P\u0159edlo\u017Een\u00FD projekt je zam\u011B\u0159en na c\u00EDlen\u00E9 (\u0159\u00EDzen\u00E9) ovliv\u0148ov\u00E1n\u00ED rozhran\u00ED mezi ne\u017Eiv\u00FDm materi\u00E1lem implant\u00E1t\u016F a pojivovou tk\u00E1n\u00ED se z\u0159etelem k zaji\u0161t\u011Bn\u00ED tolerov\u00E1n\u00ED p\u0159\u00EDtomnosti implant\u00E1tu hostitelsk\u00FDm biologick\u00FDm materi\u00E1lem, k zaji\u0161t\u011Bn\u00ED velk\u00E9 plo\u0161n\u00E9 hustotyvazeb atom\u016F pojivov\u00E9 tk\u00E1n\u011B s atomy na povrchu kompozitu a k zaji\u0161t\u011Bn\u00ED biointegrity adhezn\u00EDch film\u016F (vazebn\u00FDch medi\u00E1tor\u016F) se \u017Eivou tk\u00E1n\u00ED. \u0158\u00EDzen\u00ED biofixace bude realizov\u00E1no: a) biomechanicky - \u0159\u00EDzen\u00EDm gradientu elastick\u00FDch vlastnost\u00ED kompozitu tak, aby najeho rozhran\u00ED se \u017Eivou tk\u00E1n\u00ED byly moduly pru\u017Enost\u00ED bl\u00EDzk\u00E9 k modul\u016Fm pru\u017Enosti \u017Eiv\u00E9 tk\u00E1n\u011B (na p\u0159\u00EDklad kompakty), b) biofyzik\u00E1ln\u011B - \u0159\u00EDzen\u00EDm hustot vazebn\u00FDch pol\u00ED mezi atomy kompozitu a atomy aminokyselin kolagenu, a to iontovou implantac\u00ED %22vazebn\u00FDmi%22 atomypovrchu kompozitu, c) biochemicky - \u0159\u00EDzen\u00EDm stimulace proliferace a diferenciace bun\u011Bk pomoc\u00ED adhezn\u00EDho filmu (vazebn\u00E9ho medi\u00E1toru kopolymeru biologick\u00E9ho p\u016Fvodu) - \u0159\u00EDzen\u00ED kolonizace rozhran\u00ED kompozitu se \u017Eivou tk\u00E1n\u00ED osteogenn\u00EDmi bu\u0148kami. C\u00EDlem \u00FAkolu je:" . . . . "\u0158\u00EDzen\u00ED bioadhese pojivov\u00E9 tk\u00E1n\u011B k polymerov\u00FDm kompozit\u016Fm" . . . . . . . . . . "Cycloolefinic copolymer (COC) has been chosen as a material for skeletal implants. This material shows the proper combination of mechanical and rheological properties. Moreover, biocompatibility with living tissue was proven. COC is possible to modify wi"@en . "1"^^ . . . . "2"^^ . "The presented Project is aimed at targeted (controlled) influencing of the contact point between the artificial implant material and the connecting tissue in order to ensure implant tolerability by a host biological material, to ensure a high density ofatomic bonds between the connecting tissue and the implant surface atoms and to ensure the biointegrity of adhesive films (binding mediators) and living tissues. Biofixation shall be controlled: a) biomechanicallv - by controlling the gradient ofcomposite elastic properties in order to achieve elastic modules at the contact point with the living tissue which would be similar to those of the living tissue (e.g. compacta), b) biophysically - by controlling the density of bonding fields between thecomposite atoms and the atoms of collagen amino-acids, through ion implantation of %22binding atoms%22 into the composite surface, c) biochemically - by controlling cell proliferation and stimulation using an adhesive film (a binding mediator - copolymer of"@en .