. . . . . . "5"^^ . "Se zvy\u0161uj\u00EDc\u00ED se incidenc\u00ED n\u00E1dorov\u00FDch onemocn\u011Bn\u00ED vzr\u016Fst\u00E1 pot\u0159eba identifikace nov\u00FDch biomarker\u016F pro \u010Dasn\u011Bj\u0161\u00ED z\u00E1chyt a odhad progn\u00F3zy u onkologick\u00FDch diagn\u00F3z. U p\u011Bti hlavn\u00EDch onkologick\u00FDch diagn\u00F3z (karcinom prostaty, ledviny, mo\u010Dov\u00E9ho m\u011Bch\u00FD\u0159e, slinivky b\u0159i\u0161n\u00ED a tlust\u00E9ho st\u0159eva) provedeme vy\u0161et\u0159en\u00ED s\u00E9ra nebo mo\u010Di pacient\u016F na p\u0159\u00EDtomnost definovan\u00FDch biomarker\u016F a stanov\u00EDme specificitu a senzitivitu jednotliv\u00FDch biomarker\u016F ve vztahu k diagnostice nebo ur\u010Den\u00ED progn\u00F3zy n\u00E1doru. U ka\u017Ed\u00E9 diagn\u00F3zy bude zkoum\u00E1no patn\u00E1ct biomarker\u016F pomoc\u00ED komer\u010Dn\u011B dostupn\u00FDch esej\u00ED. Na z\u00E1klad\u011B statistick\u00E9ho zpracov\u00E1n\u00ED bude vybr\u00E1no n\u011Bkolik kandid\u00E1tn\u00EDch biomarker\u016F pro ka\u017Edou diagn\u00F3zu. V druh\u00E9 f\u00E1zi projektu prob\u011Bhne v\u00FDvoj diagnostick\u00E9ho panelu biomarker\u016F pro ka\u017Edou diagn\u00F3zu metodou pr\u016Ftokov\u00E9 cytometrie a p\u0159\u00EDprava t\u011Bchto panel\u016F ke komer\u010Dn\u00EDmu pou\u017Eit\u00ED." . "5"^^ . "tumour markers" . "With a still rising incidence of malignant tumours, identification of new biomarkers for earlier detection and prediction of prognosis in oncological diseases is urgently needed. The serum or urine of patients will be tested for presence of defined biomarkers in five main oncological diseases ( prostate cancer, urinary bladder cancer, renal clear cell carcinoma, pancreatic cancer and colorectal cancer ). We will then assess the specificity and sensitivity of every single biomarker in relation to diagnosis or prognosis prediction. Fifteen biomarkers will be tested by commercially available assays in each tumour. Based on the statistical evaluation then a few candidate biomarkers in each disease will be selected. In the second part of the project the diagnostic panel of these biomarkers will be developed for each diagnosis by method of flow cytometry and these panels will be prepared for commercial application."@en . "2014-09-30+02:00"^^ . . " prostate cancer" . . . "0"^^ . "2013-04-23+02:00"^^ . "tumour markers; prostate cancer; bladder cancer; renal cell carcinoma; colorectal cancer; pancreatic cancer"@en . . "1"^^ . "http://www.isvav.cz/projectDetail.do?rowId=FR-TI3/666"^^ . . "1"^^ . " colorectal cancer" . " renal cell carcinoma" . . . "Stanoven\u00ED panelu nov\u00FDch n\u00E1dorov\u00FDch marker\u016F u vybran\u00FDch onkologick\u00FDch onemocn\u011Bn\u00ED" . . " bladder cancer" . "Identification of novel biomarkers panels in selected malignancies"@en . . . . "2011-04-01+02:00"^^ . . "FR-TI3/666" . "2015-01-22+01:00"^^ .