" enzymes" . . " nanotechnology" . "Projekt pova\u017Eujeme z odborn\u00E9ho i komer\u010Dn\u00EDho hlediska za \u00FAsp\u011B\u0161n\u00FD, nebo\u0165 se poda\u0159ilo p\u0159ipravit produkty s v\u00FDrazn\u00FDm potenci\u00E1lem dal\u0161\u00EDho vyu\u017Eit\u00ED. Produkty byly pr\u016Fm. chr\u00E1n\u011Bny."@cs . . " degradable polymer" . . . . "2012-12-31+01:00"^^ . . "*Podstatnou \u010D\u00E1st\u00ED projektu je realizace aplikovan\u00E9ho v\u00FDzkumu a experiment\u00E1ln\u00EDho v\u00FDvoje p\u0159\u00EDpravy a vyu\u017Eit\u00ED polymern\u00EDch nanovl\u00E1kenn\u00FDch nosi\u010D\u016F k \u0159\u00EDzen\u00FDm aplikac\u00EDm proteolytick\u00FDch enzym\u016F a farmakologicky aktivn\u00EDch l\u00E1tek. Vazba t\u011Bchto biologicky aktivn\u00EDch molekul na nanovl\u00E1kenn\u00FD materi\u00E1l je realizov\u00E1na jednak kovalentn\u00EDmi metodami, kter\u00E9 zaji\u0161\u0165uj\u00ED minim\u00E1ln\u00ED ne\u017E\u00E1douc\u00ED uvol\u0148ov\u00E1n\u00ED z materi\u00E1lu, nebo prostou inkorporaci aktivn\u00ED l\u00E1tky do polymern\u00ED roztoku. Velk\u00FD specifick\u00FD povrch nanovl\u00E1ken v\u00FDrazn\u011B zvy\u0161uje potenci\u00E1l bioaktivn\u00EDch l\u00E1tek. C\u00EDlenou aplikac\u00ED modifikovan\u00E9 nanovl\u00E1kenn\u00E9 membr\u00E1ny je p\u0159ednostn\u011B o\u0161et\u0159en\u00ED poran\u011Bn\u00E9 k\u016F\u017Ee s potenci\u00E1lem roz\u0161\u00ED\u0159en\u00E9ho vyu\u017Eit\u00ED ve farmacii pro \u0159\u00EDzen\u00E9 uvol\u0148ov\u00E1n\u00ED l\u00E9\u010Div, p\u0159edev\u0161\u00EDm v sublingv\u00E1ln\u00ED aplikaci. Navazuj\u00EDc\u00ED f\u00E1ze \u0159e\u0161en\u00ED projektu bude zam\u011B\u0159ena na pilotn\u00ED preklinick\u00E9 hodnocen\u00ED technologicky zvl\u00E1dnut\u00FDch a konkr\u00E9tn\u011B vyu\u017Eiteln\u00FDch p\u0159\u00EDpravk\u016F." . "5"^^ . "2009-04-01+02:00"^^ . "5"^^ . . "biofunctionalized nanofiber carrier; degradable polymer; drugs; enzymes; nanotechnology; nanofibers"@en . . "2012-04-10+02:00"^^ . . . "biofunctionalized nanofiber carrier" . "Project is considered the profesional and comercial point of vein as successfull. We managed to prepare product with potencial for further use."@en . . . . "0"^^ . " drugs" . "1"^^ . "1"^^ . . . . "http://www.isvav.cz/projectDetail.do?rowId=FR-TI1/436"^^ . . "FR-TI1/436" . "2014-07-14+02:00"^^ . "*Vyu\u017Eit\u00ED nanovl\u00E1kenn\u00FDch membr\u00E1n pro \u0159\u00EDzen\u00E9 uvol\u0148ov\u00E1n\u00ED aktivn\u00EDch l\u00E1tek" . . "*Proposed project is an application of the field of polymeric nanofiber material and its functionalization by proteolytic enzymes and drugs. The attachment of the enzymes is preferably covalent, decreasing the unwanted release of active compounds , for drugs by incorporation required substances into the polymer solution before electro spinning. Large specific surface of nanofiber polymers considerably increases the amount of bioactive substances. Application of this nanofiber technology is in cutaneous dressing for wound healing with potential of usage in pharmacy-chemistry for controlled drug release."@en . . "*Nanofiber membranes utilization for controlled release of active compounds"@en .