. . . "0"^^ . . "1"^^ . . "0"^^ . "The project supports the establishment of the Czech Centre of Phenogenomics (CCP) and prepares its full integration into the international consortium Infrafrontier. Infrafrontier deals with systematic, standardized, functional annotation of genes using animal models and the main goal of the Czech partner is to establish own program of \u201Cfunctional genomics\u201D including infrastructure for generation of genetically modified mouse models, their cryo-archiving, and their distribution to the users and researches. This project establishes functional analysis of the role of individual genes in cooperation with international and Czech partners. CCP creates great opportunities for individual specialized research groups as it provides functional description of gene function in many individual organs and all main physiological systems. Thus, the individual specialized research groups can effectively characterize molecular mechanisms that provide fundament to reveal specific phenotypes. Program and preparation period for integration of CCP into the international consortium cover two main fields: archiving and distribution of mouse models/mutants (Archivefrontier/EMMA, European mouse mutant archive) and phenotyping (Phenomefrontier, i.e. functional characterization of genes)"@en . "0"^^ . . . . "Hodnocen\u00ED v\u00FDsledk\u016F \u0159e\u0161en\u00ED ministerstvo neprov\u00E1d\u00ED, nebo\u0165 podm\u00EDnkou podpory je, \u017Ee uchaze\u010D byl vybr\u00E1n mezin\u00E1rodn\u00EDm poskytovatelem v souladu s pravidly p\u0159\u00EDslu\u0161n\u00E9ho programu. Projekt je hodnocen a\u017E po jeho schv\u00E1len\u00ED mezin\u00E1rodn\u00EDm poskytovatelem."@cs . . . "gene" . " mutation" . . "Projekt p\u0159isp\u00EDv\u00E1 k etablov\u00E1n\u00ED \u010Cesk\u00E9ho Centra Fenogenomiky (CCP, Czech Centre for Phenogenomics) a p\u0159ipravuje ho k napojen\u00ED na mezin\u00E1rodn\u00ED konsorcium Infrafrontier. Infrafrontier se zab\u00FDv\u00E1 systematickou standardizovanou funk\u010Dn\u00ED anotac\u00ED gen\u016F pomoc\u00ED zv\u00ED\u0159ec\u00EDch model\u016F a hlavn\u00EDm c\u00EDlem \u010Desk\u00E9ho partnera je etablov\u00E1n\u00ED programu funk\u010Dn\u00ED genomiky, tvorby geneticky zm\u011Bn\u011Bn\u00FDch my\u0161\u00EDch model\u016F a jejich kryoarchivov\u00E1n\u00ED a distribuce u\u017Eivatel\u016Fm. Tento projekt p\u0159ipravuje funk\u010Dn\u00ED anal\u00FDzu role jednotliv\u00FDch gen\u016F v kooperaci s mezin\u00E1rodn\u00EDmi a \u010Desk\u00FDmi partnery. P\u0159i popisu fenotyp\u016F mutantn\u00EDch model\u016F v jednotliv\u00FDch org\u00E1nech \u010Di fyziolog\u00FDch celc\u00EDch vytv\u00E1\u0159\u00ED CCP velk\u00FD potenci\u00E1l pro jednotliv\u00E9 specializovan\u00E9 v\u011Bdeck\u00E9 skupiny, kter\u00E9 pak mohou efektivn\u011B charakterizovat molekul\u00E1rn\u00ED mechanismy funkc gen\u016F, je\u017E se odr\u00E1\u017E\u00ED ve specifick\u00E9m fenotypu. Program i p\u0159\u00EDprava zapojen\u00ED jsou funk\u010Dn\u011B rozd\u011Bleny do dvou oblast\u00ED: archivace a distribuce my\u0161\u00EDch model\u016F/mutant\u016F (Archivefrontier/EMMA, European mouse mutant archive) a fenotypizace (Phenomefrontier, t.j. funk\u010Dn\u00ED charakterizace genu)." . "Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider."@en . . . "gene; mutation; phenotypisation; cryopreservation; mouse models; archiving and distribution of mouse models"@en . "Czech node of INFRAFRONTIER - The European infrastructure for phenotyping and archiving of model mammalian genomes"@en . " cryopreservation" . " phenotypisation" . "\u010Cesk\u00E9 centrum INFRAFRONTIER - The European infrastructure for phenotyping and archiving of model mammalian genomes" . . . "2012-12-31+01:00"^^ . "2012-01-01+01:00"^^ . "7E12089" . . "http://www.isvav.cz/projectDetail.do?rowId=7E12089"^^ . " mouse models" . . . "2013-06-28+02:00"^^ . . "2012-11-29+01:00"^^ . "0"^^ . .