"2012-03-15+01:00"^^ . . "2013-06-28+02:00"^^ . "HIV" . " LEDGF/p75" . . "7E08066" . . . "TARGETING HIV INTEGRATION CO-FACTORS, TARGETING CELLULAR PROTEINS DURING NUCLEAR IMPORT OR INTEGRATION OF HIV"@en . "Standard therapy of infection with the human immunodeficiency virus type 1 (HIV-1) is based on potent cocktails of drugs targeting viral proteins. This treatment is associated with severe side effects and is almost unaffordable for the patients living in sub-Saharan Africa. Incomplete suppression of HIV replication results in drug-resistance. Therefore, a continued research effort is required to develop more potent, cheaper and less toxic antivirals. The insight has grown that HIV requires cellular proteins to serve as co-factors for viral replication. Our over-all objective is to develop novel drugs by targeting co-factors required for HIV replication. The virus will find it difficult to develop antiviral resistance against drugs targeting interaction between invariable cellular proteins and conserved viral protein domains. We will focus on the cellular proteins that mediate HIV trafficking, nuclear import and integration, such as Lens Epithelium Derived Growth Factor (LEDGF/p75), a novel cof" . . "Standard therapy of infection with the human immunodeficiency virus type 1 (HIV-1) is based on potent cocktails of drugs targeting viral proteins. This treatment is associated with severe side effects and is almost unaffordable for the patients living in sub-Saharan Africa. Incomplete suppression of HIV replication results in drug-resistance. Therefore, a continued research effort is required to develop more potent, cheaper and less toxic antivirals. The insight has grown that HIV requires cellular proteins to serve as co-factors for viral replication. Our over-all objective is to develop novel drugs by targeting co-factors required for HIV replication. The virus will find it difficult to develop antiviral resistance against drugs targeting interaction between invariable cellular proteins and conserved viral protein domains. We will focus on the cellular proteins that mediate HIV trafficking, nuclear import and integration, such as Lens Epithelium Derived Growth Factor (LEDGF/p75), a novel cof"@en . . "2008-03-01+01:00"^^ . . " antiviral drugs" . . . . "http://www.isvav.cz/projectDetail.do?rowId=7E08066"^^ . . . "TARGETING HIV INTEGRATION CO-FACTORS, TARGETING CELLULAR PROTEINS DURING NUCLEAR IMPORT OR INTEGRATION OF HIV" . "Following the condition that the candidate of financial contribution was evaluated and afterwards selected by international provider in accordance with the rules of the program the Ministry of Education, Youth ans Sports does not realize the evaluation of project results. The project is evaluated only after its approval by an international provider."@en . " co-factors" . " integration" . " import" . . . "Hodnocen\u00ED v\u00FDsledk\u016F \u0159e\u0161en\u00ED ministerstvo neprov\u00E1d\u00ED, nebo\u0165 podm\u00EDnkou podpory je, \u017Ee uchaze\u010D byl vybr\u00E1n mezin\u00E1rodn\u00EDm poskytovatelem v souladu s pravidly p\u0159\u00EDslu\u0161n\u00E9ho programu. Projekt je hodnocen a\u017E po jeho schv\u00E1len\u00ED mezin\u00E1rodn\u00EDm poskytovatelem."@cs . . "2012-02-29+01:00"^^ . "HIV; AIDS; co-factors; LEDGF/p75; antiviral drugs; resistance; integration; import; protein protein interaction"@en . "0"^^ . . . "1"^^ . . " AIDS" . "1"^^ . . "0"^^ . . "1"^^ . " resistance" .