. . "2014-03-17+01:00"^^ . . "2015-05-28+02:00"^^ . "Mechanismy odpov\u011Bdn\u00E9 za p\u0159e\u017E\u00EDv\u00E1n\u00ED p\u016Fvodce \u010Dern\u00E9ho ka\u0161le v lidsk\u00FDch fagocytech" . . . "http://www.isvav.cz/projectDetail.do?rowId=7AMB14AR028"^^ . . . . . . . "0"^^ . "2015-12-31+01:00"^^ . "7AMB14AR028" . . . . "1"^^ . "0"^^ . "2014-01-01+01:00"^^ . . "0"^^ . "Mechanisms underlying survival of the whooping cough agent inside human phagocytes"@en . "Bordetella pertussis"@en . . . . "0"^^ . "The goal of this project is to develop a coordinated collaboration and the necessary synergy of the Czech and Argentinian teams that are about to apply complementary approaches to studies on intracellular survival of the whooping cough agent Bordetella pertussis inside human phagocytes. By joint efforts the virulence factors important for survival of the bacteria inside macrophage cells will be identified and their regulation and role in inhibition of bactericidal functions of the phagocytic cells will be elucidated. Such basic knowledge is sorely needed for development of next generation pertussis vaccines."@en . . "C\u00EDlem projektu je prost\u0159ednictv\u00EDm koordinovan\u00E9 spolupr\u00E1ce \u010Desk\u00E9ho a argentinsk\u00E9ho v\u00FDzkumn\u00E9ho t\u00FDmu vytvo\u0159it synergii mezi jimi rozv\u00EDjen\u00FDmi komplement\u00E1rn\u00EDmi p\u0159\u00EDstupy ke studiu intracelul\u00E1rn\u00EDho p\u0159e\u017E\u00EDv\u00E1n\u00ED bakt\u00E9rie Bordetella pertussis v lidsk\u00FDch fagocytech. Spole\u010Dn\u00FDm \u00FAsil\u00EDm pak budou identifikov\u00E1ny a validov\u00E1ny faktory virulence t\u00E9to bakt\u00E9rie a mechanismy regulace jejich exprese ve fagocytech, s c\u00EDlem objasnit jejich roli p\u0159i inhibici baktericidn\u00EDch funkc\u00ED fagocyt\u016F a intracelul\u00E1rn\u00EDm p\u0159e\u017E\u00EDv\u00E1n\u00ED p\u016Fvodce d\u00E1viv\u00E9ho ka\u0161le. Takov\u00E9 z\u00E1kladn\u00ED pozn\u00E1n\u00ED je urgentn\u011B zapot\u0159eb\u00ED pro v\u00FDvoj nov\u00E9 generace vakc\u00EDn proti pertusi." .