"2B08064" . . . . "2011-12-31+01:00"^^ . "2008-03-01+01:00"^^ . "2011-02-25+01:00"^^ . . " secondary metabolic genes" . "http://www.isvav.cz/projectDetail.do?rowId=2B08064"^^ . "1"^^ . "2"^^ . "The proposed project aims in testing modern molecular genetic methods employed in preparation of organisms producing new biologically active compounds. Lincosamide and anthramycin antibiotics, two groups differing in structure and function but sharing part of their biosynthetic pathway will be used as models. The partial overlap of their biosynthetic pathways will be used to design hybrid compounds promising a widened spectrum of antibacterial, anti-parasitic (anti-malaria in particular), and possibly also anti-tumor effects. The outcome, among others, will be a collection of genes isolated from producers of defined compounds as well as of genes gathered in the natural environment potentially useful in construction of organisms producing the above mentioned hybrid compounds."@en . " anthramycins" . "0"^^ . "lincosamides" . . . "This project has been performed in very high quality with many excellent results involving research papers, patents, new methods and tools for future continuation. In addition, it is necessary to point out education aspects of the project that even increase its value. The results of this project will not be lost. In general, this project can be marked as excellent."@en . "lincosamides; anthramycins; secondary metabolic genes; hybrid antibiotics"@en . "2012-07-03+02:00"^^ . "14"^^ . "14"^^ . "\u017Divotn\u00ED prost\u0159ed\u00ED jako zdroj bioaktivn\u00EDch l\u00E1tek pro lidsk\u00E9 zdrav\u00ED" . "Projekt byl \u0159e\u0161en vynikaj\u00EDc\u00EDm zp\u016Fsobem se spoustou kvalitn\u00EDch v\u00FDsledk\u016F publikovan\u00FDch v dobr\u00FDch \u010Dasopisech, s uplatn\u011Bn\u00FDmi patenty a nov\u00FDmi metodikami \u010Di n\u00E1stroji pro budouc\u00ED pokra\u010Dov\u00E1n\u00ED. P\u0159idanou hodnotou projektu byl jeho vzd\u011Bl\u00E1vac\u00ED aspekt. V\u00FDsledky projektu rozhodn\u011B nezapadnou. Celkov\u011B OPO hodnot\u00ED projekt jako v\u00FDborn\u011B spln\u011Bn\u00FD."@cs . . . . . . . . . "Introduction of producers generating new and modified antibiotics."@en . . . . . . "Znalosti biosynt\u00E9zy antibiotik vyu\u017E\u00EDt k vyhled\u00E1v\u00E1n\u00ED analogick\u00FDch gen\u016F a shluk\u016F. Vytvo\u0159it sb\u00EDrku gen\u016F vyu\u017Eiteln\u00FDch pro c\u00EDlenou p\u0159\u00EDpravu hybridn\u00EDch l\u00E1tek, tj. ke \u0161lecht\u011Bn\u00ED produk\u010Dn\u00EDch organism\u016F i kmen\u016F degraduj\u00EDj\u00EDc\u00ED v\u00FDznamn\u00E9 antropogenn\u00ED kontaminanty vody." . .