. "3"^^ . "1"^^ . " nukleotidov\u00FD analog" . . . "Byly vyvinuty nov\u00E9 inhibitory bakteri\u00E1ln\u00ED RNA polymer\u00E1zy a antibakteri\u00E1ln\u00ED l\u00E1tky. V\u00FDznamnou skupinou mezi t\u011Bmito l\u00E1tkami jsou tzv. lipofosfonoxiny, kter\u00E9 jsou \u00FA\u010Dinn\u00E9 proti \u0159ad\u011B bakteri\u00E1ln\u00EDch druh\u016F v\u010Detn\u011B multirezistentn\u00EDch kmen\u016F a z\u00E1rove\u0148 vykazuj\u00ED n\u00EDzk\u00E9 hodnoty cytotoxicity v\u016F\u010Di lidsk\u00FDm tk\u00E1\u0148ov\u00FDm lini\u00EDm. Tyto l\u00E1tky maj\u00ED perspektivu jako potenci\u00E1ln\u00ED antibiotika."@cs . "antibiotika, bakterie, nukleotidov\u00FD analog, patogen, riboz\u00F3m, RNA polymer\u00E1za"@en . . . "2011-06-30+02:00"^^ . "0"^^ . . "2011-02-25+01:00"^^ . "2012-07-03+02:00"^^ . . . . . . " riboz\u00F3m" . . " bakterie" . "2006-07-01+02:00"^^ . "Pathogens and opportunistic infections of bacterial origin resistant to existing antibiotics present a major medical and economical problem. The project %22New Generation of Antibacterial Agens%22 proposes to develop antibiotics targeting the synthesis of new ribosomes in bacteria. The ribosomes are required for bacterial growth, division, and spread of the infection. Utilizing cutting edge approaches of molecular biology, organic chemistry, and computer modeling, novel nucleotide analogues will be developed. The nucleotide analogues will block the active site / access to the active site of bacterial RNA polymerase (RNAP). RNAP is a key cellular enzyme that is required for the synthesis of ribosomal RNA, an essential part of the ribosome. Effective molecules will be optimized for the entry into the bacterial cell. Since the active site of RNAP is generally well conserved, the new antibiotics compromising this site will have a broad range of bacterial targets, minimizing the risk of appearance of spontane"@en . . . "Antibakteri\u00E1ln\u00ED l\u00E1tky nov\u00E9 generace" . . . "New Generation of Antibacterial Agens"@en . . . "26"^^ . "26"^^ . "New inhibitors of bacterial RNA polymerase and antibacterial compounds were developed. An important group among these compounds are lipophosphonoxins. Lipophosphonoxins are active against a number of bacterial species including multiresistant strains while displaying low cytotoxicity towards human cell lines. Lipophosphonoxins have a potential as future antibiotics."@en . "antibiotika" . " patogen" . "2B06065" . "http://www.isvav.cz/projectDetail.do?rowId=2B06065"^^ . . . "Patogeny a oportunistick\u00E9 infekce bakteri\u00E1ln\u00EDho p\u016Fvodu rezistentn\u00ED k dostupn\u00FDm antibiotik\u016Fm jsou v sou\u010Dasnosti velk\u00FDm medic\u00EDnsk\u00FDm a ekonomick\u00FDm probl\u00E9mem. Program %22Antibakteri\u00E1ln\u00ED l\u00E1tky nov\u00E9 generace%22 se zam\u011B\u0159uje na v\u00FDvoj nov\u00FDch antibiotik blokuj\u00EDc\u00EDch bakteri\u00E1ln\u00ED r\u016Fst. Bun\u011B\u010Dn\u00FDm procesem, kter\u00FD bude blokov\u00E1n je vznik nov\u00FDch riboz\u00F3m\u016F, kter\u00E9 jsou nutn\u00E9 pro d\u011Blen\u00ED bakteri\u00ED a dal\u0161\u00ED \u0161\u00ED\u0159en\u00ED infekce. Pomoc\u00ED nejmodern\u011Bj\u0161\u00EDch metod molekul\u00E1rn\u00ED biologie, organick\u00E9 chemie, a v\u00FDpo\u010Detn\u00ED techniky budeme vyv\u00EDjet nukleotidov\u00E9 analogy, kter\u00E9 budou blokovat aktivn\u00ED m\u00EDsto / p\u0159\u00EDstup k aktivn\u00EDmu m\u00EDstu bakteri\u00E1ln\u00ED RNA polymer\u00E1zy, kl\u00ED\u010Dov\u00E9ho bun\u011B\u010Dn\u00E9ho enzymu nezbytn\u00E9ho pro synt\u00E9zu rRNA, z\u00E1kladn\u00EDho stavebn\u00EDho kamene riboz\u00F3m\u016F. \u00DA\u010Dinn\u00E9 l\u00E1tky budou optimalizov\u00E1ny z hlediska vstupu do bakteri\u00E1ln\u00ED bu\u0148ky. Takto vyvinut\u00E1 antibiotika budou m\u00EDt \u0161irok\u00E9 vyu\u017Eit\u00ED, proto\u017Ee budou zac\u00EDlena proti konzervovan\u00E9 \u010D\u00E1sti bakteri\u00E1ln\u00EDho enzymu, co\u017E zajist\u00ED \u0161irokospektr\u00FD \u00FA\u010Dinek a sn\u00ED\u017Een\u00ED pravd\u011Bpodobnosti vzniku rezistentn\u00EDch mutac\u00ED." .