"2012-07-03+02:00"^^ . . "Anal\u00FDza genov\u00E9 exprese v predikci a prevenci diabetu 1.typu" . . "8"^^ . "2B06019" . "The research activities have been realized in agreement with the project goals. Original results bring important output for both research and clinical practice. Proposed novel approaches may contribute to early diagnosis of type1 diabetes."@en . . "Type 1 diabetes is an autoimmune disease which is characterised by the destruction of insulin producing pancreatic beta cells. In this process autoreactive T cells play the major role. The purpose of the proposed project is to analyse gene expression of96 immunorelevant genes in peripheral blood mononuclear cells prior and post stimulation with diabetogeneic autoantigens. We plan to test T1D patients, their relatives and healthy controls. We suppose that proposed project results will be used in clinicalpraxis in T1D prediction and eventually for T1D prevetion as well."@en . " autoantigeny" . "8"^^ . "Gene expression analysis in type 1 diabetes prediction and prevention"@en . . . "diabetes" . . . "2011-02-25+01:00"^^ . . " prevence" . . . . . . "2011-06-30+02:00"^^ . . . . . "1"^^ . . "Projekt byl realizov\u00E1n v souladu se zadan\u00FDmi c\u00EDli. Origin\u00E1ln\u00ED v\u00FDsledky p\u0159in\u00E1\u0161ej\u00ED v\u00FDznamn\u00E9 v\u00FDstupy jak pro v\u00FDzkum, tak pro klinickou praxi. Navr\u017Een\u00E9 nov\u00E9 postupy p\u0159isp\u011Bj\u00ED k \u010Dasn\u00E9 diagnostice diabetu 1. typu."@cs . "diabetes, autoimunita, genov\u00E1 exprese, predikce, prevence, autoantigeny, inzulitida"@en . "1"^^ . "Diabetes 1.typu (T1D)je autoimunitn\u00ED choroba, p\u0159i kter\u00E9 doch\u00E1z\u00ED k postupn\u00E9 destrukci pankreatick\u00FDch beta bun\u011Bk produkuj\u00EDc\u00EDch inzul\u00EDn. Kl\u00ED\u010Dov\u00E1 role je v tomto procesu p\u0159ipisov\u00E1na autoreaktivn\u00EDm T lymfocyt\u016Fm. C\u00EDlem projektu je analyzovat genovou expresi 96imunorelevantn\u00EDch gen\u016F v perifern\u00EDch krevn\u00EDch mononukle\u00E1rn\u00EDch bu\u0148k\u00E1ch p\u0159ed a po stimulaci syntetick\u00FDmi diabetogenn\u00EDmi autoantigeny.Pl\u00E1nujeme vy\u0161et\u0159ovat pacienty s T1D, jejich p\u0159\u00EDbuzn\u00E9 a zdrav\u00E9 kontroly.O\u010Dek\u00E1v\u00E1me,\u017Ee v\u00FDsledky projektu budou m\u00EDt konkr\u00E9tn\u00EDvyu\u017Eit\u00ED v predikci a prevenci t\u00E9to z\u00E1va\u017En\u00E9 choroby." . . " predikce" . "0"^^ . . "2006-07-01+02:00"^^ . " genov\u00E1 exprese" . "http://www.isvav.cz/projectDetail.do?rowId=2B06019"^^ . " autoimunita" .