. . . . "2007-07-03+02:00"^^ . "Biosimilars - budov\u00E1n\u00ED znalostn\u00ED z\u00E1kladny pro v\u00FDrobu terapeutick\u00FDch protein\u016F za pou\u017Eit\u00ED heterologn\u00EDch expresn\u00EDch syst\u00E9m\u016F (\u00DAstav fyzik\u00E1ln\u00ED biologie)." . "The project Biosimilars resulted in three technologies which may be utilised for production of therapeutic peptides and proteins. The technology using the fusion with fluorescent protein has potential to significantly decrease production costs."@en . . . "2A-2TP1/030" . "V\u0161echny v\u00FDsledky projektu jsou kome\u010Dn\u011B vyu\u017Eiteln\u00E9. (produk\u010Dn\u00ED plastmidy pro heterogen\u00ED expresi hormon\u00E1ln\u00EDho fragmentu teriparatide, metoda exprese peptidov\u00FDch fragment\u016F.)"@cs . "Biogenerics; biosimilar; therapeutic protein; expression systems; post-translational modification."@en . " therapeutic protein" . . "Proteiny vyr\u00E1b\u011Bn\u00E9 v heterologn\u00EDch expresn\u00EDch syst\u00E9mech jsou nejrychleji rostouc\u00EDm segmentem farmaceutick\u00E9ho pr\u016Fmyslu. Bl\u00ED\u017E\u00EDc\u00ED se ukon\u010Den\u00ED platnosti n\u011Bkter\u00FDch patentov\u00FDch ochran zvy\u0161uje tlak na generick\u00E9 firmy k zaveden\u00ED v\u00FDrob biogenerik-biosimilars. Rozsah a detailn\u00ED podm\u00EDnky vyu\u017Eit\u00ED jednotliv\u00FDch expresn\u00EDch syst\u00E9m\u016F, kvasni\u010Dn\u00FDch i pokro\u010Dilej\u0161\u00EDch zalo\u017Een\u00FDch na sav\u010D\u00EDch bun\u011B\u010Dn\u00FDch lini\u00EDch, bude systematicky testov\u00E1n v tomto projektu. V\u00FDstupem bude zaveden\u00ED nov\u00FDch expresn\u00EDch syst\u00E9m\u016F, syst\u00E9m\u016F zpracov\u00E1n\u00ED a analytick\u00FDch p\u0159\u00EDstup\u016F (aplikovan\u00FD v\u00FDzkum) a pr\u016Fzkum technik nutn\u00FDch pro v\u00FDvoj nejm\u00E9n\u011B dvou konkr\u00E9tn\u00EDch produkt\u016F (pr\u016Fmyslov\u00FD v\u00FDzkum)." . . . " expression systems" . . "Biogenerics" . "2012-07-23+02:00"^^ . . . "1"^^ . . . "3"^^ . "Proteins produced in heterologous expression systems, are the fastest growing segment in pharmaceutical industry. The approaching termination of validity of several patents opens the possibility for generic companies to enter the market. The scope and detailed utilisation of individual expression systems, yeast and more advanced such as mammalian cell lines, processing, isolation as well as product characterisation will be exploited in the project. The outputs of the project are establishment of new expression systems, processing and analytical approaches (applied research) as well as exploration of techniques necessary for further development at least two concrete products (industrial research)."@en . "0"^^ . "3"^^ . "http://www.isvav.cz/projectDetail.do?rowId=2A-2TP1/030"^^ . "0"^^ . . . . "Biosimilars building of knowledge base for production of therapeutic proteins using heterologous expression systems."@en . . "2011-05-20+02:00"^^ . . "2011-12-31+01:00"^^ . " biosimilar" .