. . . "2011-05-30+02:00"^^ . . . " PET diagnostics" . . " positron emission tomography" . " oncology" . "Gas target 20Ne(d" . . "2011-12-31+01:00"^^ . "Vyvinuty a p\u0159ipraveny ke klinick\u00FDm zkou\u0161k\u00E1m l\u00E9kov\u00E9 formy perspektivn\u00EDch PET radiofarmak zna\u010Den\u00FDch radionuklidem F18 pro diagnostiku v onkologii a neurologii, zejm\u00E9na [18F] FET, [18F] DOPA, [18F] FMISO a [18F]octreot\u00E1t."@cs . . "*The proposed project deals with development of three radiopharmaceuticals labelled with 18F for PET diagnostics in oncology and neurology: O-2-[18F]fluoroethyl-L-tyrosine ([18F]FET), 6-[18F]fluoro-L-3, 4-dihydroxyphenylalanine (6-[18F]fluoro-L-DOPA) and [18F] fluoromisonidazol. The workplace based on the gas cyclotron target using 20Ne(d, alfa)18F nuclear reaction and electrophilic [18F]F2 isotope exchange synthesis will be built up. 2-[18F]fluoro-2-deoxy-D-glucose ([18F]FDG) designed rather for general (non-specific) imagong is produced and supplied to Czech and Slovak PET workplaces at present time. There are two other preparations, [18F]NaF (for imaging of bone metastases) and 3-deoxy- 3-[18F] fluorothymidine ([18F]FLT) (for diagnostics of quickly proliferating tumours) being developed and tested at the proposers laboratory at present time."@en . . . " 4-dihydroxyphenylalanine" . . . "1"^^ . . "3"^^ . "*V\u00FDvoj PET-radiodiagnostik pro zobrazen\u00ED v onkologii a neurologii." . "0"^^ . "3"^^ . "0"^^ . " electrofile substitution of [18F]F2 O-2-[18F]fluoroethyl-L-tyrosine 6-[18F]fluoro-L-3" . . . "*V\u00FDvoj radiofarmaceutick\u00FDch p\u0159\u00EDpravk\u016F zna\u010Den\u00FDch radionuklidem 18F pro PET diagnostiku onkologick\u00FDch a neurologick\u00FDch onemocn\u011Bn\u00ED. Jedn\u00E1 se jmenovit\u011B o p\u0159\u00EDpravky O-2-[18F]fluoroethyl-L-tyrosin ([18F]FET), 6-18F]flouro-L-3, 4-dihydroxyphenylalanin (6-[18F]fluoro-L-DOPA) a [18F] fluoromisonidazol ([18F]FMISO). Pro synt\u00E9zu -[18F]DOPA) bude vybudov\u00E1no pracovi\u0161t\u011B s plynov\u00FDm cyklotronov\u00FDm ter\u010Dem na b\u00E1zi jadern\u00E9 reakce 20Ne(d,alfa)18F a synt\u00E9zy s elektrofiln\u00ED izotopovou v\u00FDm\u011Bnou [18F]F2. Na pracovi3ti navrhovatele se dosud rutinn\u011B vyr\u00E1b\u00ED a dod\u00E1v\u00E1 na \u010Desk\u00E1 a slovensk\u00E1 PET pracovi\u0161t\u011B 2-[18F]fluoro-2-deoxy-D-gluk\u00F3za ([18F]FDG), ur\u010Den\u00E1 sp\u00ED\u0161e pro nespecifick\u00E1 PET zobrazen\u00ED. Ve stadiu \u017E\u00E1dosti o registraci, resp. \u017E\u00E1dosti o povolen\u00ED klinick\u00FDch zkou\u0161ek, jsou dal\u0161\u00ED dva p\u0159\u00EDpravky: [18F] NaF ]yobrayen9 kostn9ch metast8y] a 3-deoxy-3 [18F] fluorothymidin ([18F]FLT) pro diagnostiku rychle proliferuj\u00EDc\u00EDch n\u00E1dor\u016F." . "2012-07-23+02:00"^^ . "2A-1TP1/055" . "*Development of pet-radiodiagnostics for imaging in oncology and neurology"@en . . . "alfa)18F" . "For clinical trials were developed and prepared drugs forms of perspective PET radiopharmaceuticals labelled with radionuclide F-18 for imaging diagnostic in oncology and neurology especially [18F] FET, [18F] DOPA, [18F] FMISO a [18F]octreotate."@en . "Gas target 20Ne(d,alfa)18F; electrofile substitution of [18F]F2 O-2-[18F]fluoroethyl-L-tyrosine 6-[18F]fluoro-L-3; 4-dihydroxyphenylalanine; [18F] fluoromisonidayol; positron emission tomography; PET diagnostics; PET imaging; oncology; neurology"@en . "http://www.isvav.cz/projectDetail.do?rowId=2A-1TP1/055"^^ . . . " [18F] fluoromisonidayol" . " PET imaging" . "2006-07-01+02:00"^^ .