"75"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1QS500040581"^^ . "0"^^ . "platinum" . "Pomoc\u00ED metod molekul\u00E1rn\u00ED biofyziky byl studov\u00E1n mechanismus protin\u00E1dorov\u00E9ho \u00FA\u010Dinku konven\u010Dn\u00EDch a nov\u00FDch komplex\u016F p\u0159echodn\u00FDch kov\u016F zejm\u00E9na platiny a ruthenia. Z\u00EDskan\u00E9 v\u00FDsledky budou vyu\u017Eity p\u0159i racion\u00E1ln\u00EDm designu nov\u00FDch protin\u00E1dorov\u00FDch l\u00E9k\u016F."@cs . "75"^^ . . . . "1QS500040581" . "2010-04-15+02:00"^^ . . "Metallodrugs, design and mechansim of action"@en . "2009-12-31+01:00"^^ . "P\u0159edm\u011Btem \u0159e\u0161en\u00ED tohoto projektu je v\u00FDzkum c\u00EDlen\u00FD na v\u00FDvoj nov\u00FDch metalofarmak ch\u00E1pan\u00FD jako p\u0159\u00EDpravn\u00E1 f\u00E1ze aplikovan\u00E9ho v\u00FDzkumu sm\u011Brovan\u00E9ho na dal\u0161\u00ED pr\u016Fmyslov\u00FD a zdravotnick\u00FD v\u00FDvoj. Motivace pro tento v\u00FDzkum vypl\u00FDv\u00E1 z pot\u0159eby vytvo\u0159it kvalitn\u00ED teoretick\u00E9 a metodick\u00E9 z\u00E1zem\u00ED pro v\u00FDvoj, synt\u00E9zu a aplikaci nov\u00FDch l\u00E9\u010Div proti rakovin\u011B odvozen\u00FDch od komplex\u016F kov\u016F. Protin\u00E1dorov\u00E1 \u00FA\u010Dinnost \u0159ady komplex\u016F p\u0159echodn\u00FDch kov\u016F je podm\u00EDn\u011Bna jejich schopnost\u00ED po\u0161kodit DNA. Specifick\u00FDm c\u00EDlem tohoto n\u00E1vrhu je tedy odpov\u011Bd\u011Bt na z\u00E1sadn\u00ED ot\u00E1zku - m\u016F\u017Ee modifikace vazby komplex\u016F kov\u016F k DNA a t\u00EDmto tak\u00E9 modifikace sign\u00E1ln\u00EDch drah modulovat n\u00E1sledn\u00E9 procesy v bu\u0148ce do t\u00E9 m\u00EDry, \u017Ee tato modifikace povede k opravdu odli\u0161n\u00E9mu profilu protin\u00E1dorov\u00E9 aktivity ve srovn\u00E1n\u00ED s cytostatiky ji\u017E vyu\u017E\u00EDvan\u00FDmi v klinick\u00E9 praxi? Jedn\u00E1 se tedy o v\u00FDzkum, jeho\u017E v\u00FDstupy sm\u011B\u0159uj\u00ED k vyu\u017Eit\u00ED v pr\u016Fmyslov\u00E9 a zdravotnick\u00E9 \u010Dinnosti, kdy potenci\u00E1ln\u00ED budouc\u00ED u\u017Eivatel projevuje p\u0159edem o v\u00FDsledky \u0159e\u0161en\u00ED tohoto projektu konkr\u00E9tn\u00ED z\u00E1jem." . " ruthenium" . . . "This project is focused on research aimed at design of new metallodrugs which can be characterized as a preparatory phase of applied research toward subsequent industrial and medical development. The impetus for this research results from the need to create theoretical and methodical background for design, synthesis and application of new anticancer metallodrugs. The anticancer activity of several transition metal-based coordination complexes arises from their ability to damage DNA. Hence, the overall significance of this proposal is to ask the fundamental question - can modification of DNA binding of metal-based compounds and thus cell signaling modulate downstream events such that a genuinely different profile of anticancer activity is seen in comparison to the metal-based antitumor agents already used in the clinic? The outputs of this research can be exploited in industrial and medical activities when the potential user takes concrete interest in the results of this project."@en . . . . . . "Mechanisms of antitumor effects of conventional and new metal-based compounds, such as Pt and Ru complexes, were studied with the aid of molecular biophysics methods. The results will be exploited for rational design of new antitumor drugs."@en . " DNA" . . . . " antitumor drugs" . . "platinum; ruthenium; antitumor drugs; DNA; cancer"@en . "2005-07-01+02:00"^^ . . . . "2009-03-11+01:00"^^ . . . "0"^^ . "1"^^ . "Metalofarmaka, v\u00FDvoj a mechanismus p\u016Fsoben\u00ED" .