"0"^^ . . . . . "The project is on structure-function relationship in cathepsin D protease playing a critical role in breast cancer."@en . "breast cancer, function of proteases cathepsin D"@en . . . "http://www.isvav.cz/projectDetail.do?rowId=1P04OCB20.002"^^ . "breast cancer" . . . . . . . . . "Molekul\u00E1rn\u00ED mechanismus funkce proteas p\u0159i n\u00E1doru prsu" . "2007-06-15+02:00"^^ . . "Molecular mechanism of function of proteases in breast cancer"@en . . "C\u00EDlem projektu je anal\u00FDza vztahu molekul\u00E1rn\u00ED struktury proteas a jejich funkce v kancerogenesi a aplikace t\u011Bchto poznatk\u016F p\u0159i v\u00FDvojinov\u00FDch l\u00E9\u010Div n\u00E1doru prsu" . "Na z\u00E1klad\u011B anal\u00FDzy vztahu struktury a aktivity v molekule kathepsinu D byly navr\u017Eeny a p\u0159ipraveny nov\u00E9 molekuly reguluj\u00EDc\u00ED funkci t\u00E9to proteasy, kter\u00E1 se z\u00FA\u010Dastn\u00ED n\u00E1dorov\u00E9ho onemocn\u011Bn\u00ED prsu."@cs . . "1"^^ . "1P04OCB20.002" . "Based on analysis of the structure-activity relationship in cathepsin D, new small molecules were designed that regulate function of this protease involved in breast cancer pathogenesis."@en . "1"^^ . "0"^^ . "1"^^ . . .