. " biomarkery" . . " ekotoxicita" . " horizont\u00E1ln\u00ED p\u0159enos gen\u016F" . "\u017Eivotn\u00ED prost\u0159ed\u00ED" . . . . . . " steroidn\u00ED hormony" . "6"^^ . "\u017Eivotn\u00ED prost\u0159ed\u00ED, zdrav\u00ED a reprodukce, polutanty, voda, monoklon\u00E1ln\u00ED protil\u00E1tky, bakteri\u00E1ln\u00ED spole\u010Denstva, ekotoxicita, horizont\u00E1ln\u00ED p\u0159enos gen\u016F, biomarkery, diagnostick\u00E9 soupravy, dif\u00FAzn\u00ED zne\u010Di\u0161t\u011Bn\u00ED, steroidn\u00ED hormony, antibiotika, rezistence k antibio"@en . "\u00DA\u010Delem navrhovan\u00E9ho projektu je multidisciplin\u00E1rn\u00ED v\u00FDzkum nov\u00FDch syst\u00E9m\u016F pro monitorov\u00E1n\u00ED dif\u00FAzn\u00EDho zne\u010Di\u0161t\u011Bn\u00ED (DZ) \u017Eivotn\u00EDho prost\u0159ed\u00ED. DZ se rozum\u00ED dlouhodob\u00E1 kontaminace prost\u0159ed\u00ED velmi n\u00EDzk\u00FDmi koncentracemi polutant\u016F, rezidui rozmanit\u00FDch antropogenn\u00EDch \u010Dinnost\u00ED, s prokazateln\u011B negativn\u00EDm vlivem na \u017Eiv\u00E9 organismy i jejich reprodukci. V \u010Cesk\u00E9 republice dosud naprosto chyb\u00ED monitorovac\u00ED syst\u00E9m t\u011Bchto nebezpe\u010Dn\u00FDch l\u00E1tek v \u017Eivotn\u00EDm prost\u0159ed\u00ED. C\u00EDlem projektu je proto navrhnout a ov\u011B\u0159it ucelen\u00FD syst\u00E9m prohodnocen\u00ED DZ povrchov\u00FDch i podzemn\u00EDch vod a sediment\u016F s vyu\u017Eit\u00EDm molekul\u00E1rn\u00EDch diagnostick\u00FDch metod. Hodnot\u00EDc\u00ED syst\u00E9m bude navr\u017Een na z\u00E1klad\u011B zji\u0161t\u011Bn\u00E9ho vlivu vybran\u00FDch polutant\u016F na sav\u010D\u00ED organismus in vivo i bu\u0148ky in vitro. Diagnostika bude zalo\u017Eena nap\u0159ipraven\u00E9m panelu specifick\u00FDch monoklon\u00E1ln\u00EDch protil\u00E1tek proti vybran\u00FDm polutant\u016Fm spolu s komplexn\u00EDm molekul\u00E1rn\u011B-genetick\u00FDm popisem struktury a zm\u011Bn bakteri\u00E1ln\u00EDch konsorci\u00ED a jejich genov\u00E9 v\u00FDbavy. V\u00FDsledky nov\u011B vypracovan\u00FDch molekul\u00E1rn\u00EDch diagnostick\u00FDc" . . " dif\u00FAzn\u00ED zne\u010Di\u0161t\u011Bn\u00ED" . "1"^^ . "The Centre of Molecular Methods for Monitoring the Diffuse Pollution of the Environment."@en . . " antibiotika" . "2006-03-01+01:00"^^ . . "Byl navr\u017Een ucelen\u00FD syst\u00E9m pro monitorov\u00E1n\u00ED dif\u00FAzn\u00EDho zne\u010Di\u0161t\u011Bn\u00ED \u017Eivotn\u00EDho prost\u0159ed\u00ED polutanty zahrnuj\u00EDc\u00ED inovovan\u00E9 instrument\u00E1ln\u00ED anal\u00FDzy, molekul\u00E1rn\u011B biologick\u00E9 metody pyrosekvenov\u00E1n\u00ED, imunologick\u00E9 metody pomoc\u00ED ELISA test\u016F a testy ekotoxicity. V\u00FDvoj t\u011Bchto metod, detekce polutant\u016F a dlouhodob\u00E9 monitorov\u00E1n\u00ED je prvn\u00EDm krokem k jejich lokalizaci a n\u00E1sledn\u00E9 eliminaci ze \u017Eivotn\u00EDho prost\u0159ed\u00ED."@cs . " diagnostick\u00E9 soupravy" . "The purpose of the proposed project is a multidisciplinary research on new systems for the monitoring of diffuse environmental pollution. Diffuse pollution means a long term contamination of the environment by very low concentration of pollutants, residue of a variety of anthropogenic activities, together with a demonstrably negative influence on health and reproduction of mammals. The central focus is mainly on substances with endocrine activity such as hormonal contraceptives, certain medications including antibiotics, and substances used in detergents and paints. At present in the Czech Republic, there is no monitoring system of these dicey substances in the environment. The main aim of this project is, therefore, to design and verify an integral system for the assessment of the diffuse pollution in the environment of surface and ground water, and sediments using molecular diagnostic methods. The monitoring system will be based on the determined impact of chosen pollutants on mammalian organisms i"@en . . "0"^^ . "123"^^ . . "123"^^ . . " polutanty" . "2011-02-03+01:00"^^ . . . " monoklon\u00E1ln\u00ED protil\u00E1tky" . "Centrum molekul\u00E1rn\u00EDch metod monitorov\u00E1n\u00ED dif\u00FAzn\u00EDho zne\u010Di\u0161t\u011Bn\u00ED \u017Eivotn\u00EDho prost\u0159ed\u00ED" . " voda" . . "1M06011" . "2011-12-31+01:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1M06011"^^ . . " zdrav\u00ED a reprodukce" . "2012-07-03+02:00"^^ . . . " bakteri\u00E1ln\u00ED spole\u010Denstva" . "An integral system for monitoring diffuse environmental pollution was designed, including innovative instrumental analysis, molecular biological methods of pyrosequencing, immunological methods using ELISA and ecotoxicity tests. The development of these methods, detection of pollutants and their long-term monitoring represent the first step to their localization and elimination."@en . .