. "Navrhujeme vytvo\u0159it v\u00FDzkumn\u00E9 Centrum aplikovan\u00E9 genomiky (CAG), v n\u011Bm\u017E se skloub\u00ED vysok\u00E1 \u00FArove\u0148 genomick\u00E9ho v\u00FDzkumu s v\u00FDzkumem orientovan\u00FDm na praktick\u00E9 aplikace. Program Centra je zalo\u017Een na zku\u0161enostech z\u00EDskan\u00FDch v Centru integrovan\u00E9 genomiky (CIG) v lV CAG by se \u00FAsil\u00ED soust\u0159edilo do dvou oblast\u00ED. Jednak by to byly l\u00E9ka\u0159sky orientovan\u00E9 projekty, zam\u011B\u0159en\u00E9 zejm\u00E9na na nov\u00E9 diagnostick\u00E9 metody, a d\u00E1le projekty c\u00EDlen\u00E9 do problematiky \u017Eivotn\u00EDho prost\u0159ed\u00ED. Oba tyto sm\u011Bry jsou pr\u00E1v\u011B d\u00EDky CIG rozpracov\u00E1ny a doJako p\u0159\u00EDklad takov\u00E9ho projektu ji\u017E \u0159e\u0161en\u00E9ho v CIG lze uv\u00E9st konstrukci mito\u010Dipu, na n\u011Bm\u017E jsou zakotveny oligonukleotidov\u00E9 zna\u010Dky v\u0161ech gen\u016F lidsk\u00E9 mitochondrie. Vzhledem k dlouhodob\u00E9mu programu studia d\u011Bdi\u010Dn\u00FDch mitochondri\u00E1ln\u00EDch chorob na 1. LF UK a na FV\u00FDhodou je zde nejen zku\u0161enost s t\u011Bmito chorobami ale i dokonal\u00FD p\u0159ehled o pacientech v \u010CR i v zahrani\u010D\u00ED). Jin\u00FDm p\u0159\u00EDkladem rozvinut\u00E9 tematiky je studium bakteri\u00E1ln\u00EDch gen\u016F determinuj\u00EDc\u00EDch jednak degradaci katechol\u016F a t\u00E9\u017E synt\u00E9zu polyhydroxyalkano\u00E1t\u016F)." . . "Using methods of functional genomics molecular changes leading to several diseases were characterized. In particular this applies to porphyrias, juvenile nephropaties and diseases connected with ATP synthesis. New methods were developed for gene transfer to cells. They are based on envelope proteins of selected retroviruses. The results are subjects\u00A0of excellent scientific papers and patents"@en . . . " proteomics" . "0"^^ . "We propose to establish a research Center of Applied Genomics (CAG), where a high level research of genomics will be oriented towards practical applications. The program of the Center is based on the experience obtained in the Center of Integrated GenomiThe effort would be focused in CAG to two areas. The first one would be medically oriented projects aimed particularly at new diagnostic methods and the second one on projects targeted to the topic of the environment. Both these areas were already develoAn example of such an ongoing CIG project is construction of a mitochip on which oligonucleotide markers of all genes of the human mitochondrion are anchored. With regard to the long-term program of the study of inherited mitochondrial diseases performedAdvantageous is here experience with these diseases as well as a comprehensive register of patients in the Czech Republic and abroad. Another example of a well-developed topic is the study of bacterial genes determining degradation of catechols and synt"@en . " bioremediation" . . . "3"^^ . "1"^^ . . . "2005-01-01+01:00"^^ . . . . "Center for Applied Genomics"@en . . "2011-02-03+01:00"^^ . "1M0520" . . " microarrays" . "Genomics" . . . " inborn errors" . "2011-12-31+01:00"^^ . "Genomics, proteomics, microarrays, bioremediation, inborn errors, mitochondria"@en . . "Metodami funk\u010Dn\u00ED genomiky byly charakterizov\u00E1ny p\u0159\u00ED\u010Diny n\u011Bkolika d\u011Bdi\u010Dn\u00FDch chorob, zejm\u00E9na porfyri\u00ED, juveniln\u00EDch nefropati\u00ED a chorob spojen\u00FDch se synt\u00E9zou ATP. Poda\u0159ilo se vyvinout nov\u00E9 metody vn\u00E1\u0161en\u00ED gen\u016F do bun\u011Bk. Tyto metody vyu\u017E\u00EDvaj\u00ED obalu n\u011Bkter\u00FDch retrovir\u016F. V\u00FDsledky jsou sou\u010D\u00E1st\u00ED presti\u017En\u00EDch mezin\u00E1rodn\u00EDch publikac\u00ED a patent\u016F."@cs . "299"^^ . . "2012-07-03+02:00"^^ . . . "299"^^ . "Centrum aplikovan\u00E9 genomiky" . "http://www.isvav.cz/projectDetail.do?rowId=1M0520"^^ .