"Nov\u00E1 antivirotika a antineoplastika" . . . "New Antivirals and Antineoplastics"@en . " nucleotides" . "antineoplastics; antivirals; nucleosides; nucleotides; C-nucleosides; nucleobases; organometallic catalysis; acyclic nucleoside phosphonates; ANP; diterpenes; antimetabolites; nucleoside kinases; polymerases; telomerases; thymidine phosphorylase; angioge"@en . "288"^^ . " telomerases" . " organometallic catalysis" . "288"^^ . " diterpenes" . . " polymerases" . . . "Thousands of novel derivatives of nucleosides, terpenoids and butenolides have been synthesized and their biological activity and mechanism of action studied. New cytostatic and antiviral nucleosides, antiparazitic ANPs, antiviral carboranes, immunomudulating pyrimidines were discivered. New targets for therapy, chimeric viral particles and transport of ANPs through skin were studied."@en . . . "1"^^ . " ANP" . " nucleosides" . . "The aim of the project is to design, synthesize and study novel drug candidates for treatment of viral diseases and neoplasia, compounds active against drug resistent HIV and HBV mutants, poxviruses and RNA viruses.To study new analogs of acyclic nucleosand cytostatic effects of conformationally rigid cyclohexane nucleoside analogues, C-substituted purines with functionalized C-substituents, their nucleosides and nucleotides as DNA or RNA pol effectors and tools for broadening the genetic alphabet. To dinhibitors (PI), develop novel assays for the analysis of the development of resistance to PIs, to characterise corresponding recombinant mutated proteases (PRs) and design their efficient inhibitors. To study molecular mechanism and structural determinaof DNA viruses. To elicit specific immune response by introducing new epitopes to these capsid structures. To analyze structure, expression and activity of human glutamate carboxypeptidase II in the cancer cells of human prostate and the brain. To develo"@en . "2"^^ . " nucleobases" . "2005-01-01+01:00"^^ . "0"^^ . "1M0508" . " C-nucleosides" . . . . . . "2011-02-03+01:00"^^ . " antivirals" . . . "Bylo syntetizov\u00E1no n\u011Bkolik tis\u00EDc nov\u00FDch deriv\u00E1t\u016F nukleosid\u016F, terpenoid\u016F a butenolid\u016F a prostudov\u00E1na jejich biologick\u00E1 aktivita a mechanismus \u00FA\u010Dinku. Byly objeveny nov\u00E9 typy nukleosidov\u00FDch cytostatik a antivirotik, antiparazitick\u00FDch ANP, protivirov\u00FDch karboran\u016F, imunomudula\u010Dn\u00EDch pyrimidin\u016F apod. Byly prostudov\u00E1ny nov\u00E9 targety pro terapii, chimerick\u00E9 virov\u00E9 \u010D\u00E1stice a prostup ANP p\u0159es k\u016F\u017Ei."@cs . " acyclic nucleoside phosphonates" . " thymidine phosphorylase" . "2011-12-31+01:00"^^ . " antimetabolites" . " nucleoside kinases" . "C\u00EDlem projektu je nal\u00E9zt nov\u00E1 potenci\u00E1ln\u00ED antivirotika a l\u00E9\u010Diva s antineoplastick\u00FDm \u00FA\u010Dinkem, zejm\u00E9na l\u00E1tky \u00FA\u010Dinn\u00E9 proti rezistentn\u00EDm mutant\u016Fm HIV a HBV, poxvir\u016Fm (vakcinie, variola) a proti RNA vir\u016Fm (HCV). Za t\u00EDm \u00FA\u010Delem studovat dal\u0161\u00ED fosfon\u00E1tov\u00E9 analoStudovat p\u0159\u00EDpravu, protivirov\u00E9 a cytostatick\u00E9 \u00FA\u010Dinky konforma\u010Dn\u011B rigidn\u00EDch cyklohexanov\u00FDch analog\u016F nukle- osid\u016F, C-substituovan\u00FDch purin\u016F s funkcionalizovan\u00FDmi C-substituenty, jejich nukleosidy a nukleotidy jako efektory DNA \u010Di RNA polymeras a n\u00E1stroje rMapovat vznik mutac\u00ED proteasy (PR) z HIV positivn\u00EDch pacient\u016F l\u00E9\u010Den\u00FDch proteasov\u00FDmi inhibitory (PI), vyvi-nout metody diagnostiky v\u00FDvoje resistence proti PI, charakterizovat odpov\u00EDdaj\u00EDc\u00ED rekombinantn\u00ED PR a navrh-nout proti nim \u00FA\u010Dinn\u00E9 inhibitory. Studovatbu\u0148ky pomoc\u00ED um\u011Ble sbalen\u00FDch kapsid DNA vir\u016F. Navodit specifickou imunitn\u00ED odpov\u011Bd vlo\u017Een\u00EDm nov\u00FDch epitop\u016F do kapsidov\u00FDch struktur. Charakterizovat strukturu, expresi a aktivitu lidsk\u00E9 glutamatkarboxypeptidasy II v n\u00E1dorov\u00FDch bu\u0148k\u00E1ch prostaty a mozku. Vy" . . "2012-07-03+02:00"^^ . "antineoplastics" . . . "http://www.isvav.cz/projectDetail.do?rowId=1M0508"^^ . . .