"Sledov\u00E1n\u00ED exprese vybran\u00FDch gen\u016F u pacient\u016F s prvn\u00ED atakou neurologick\u00E9 symptomatologie suspektn\u00ED z rozvoje sclerosis multiplex p\u0159ed a po zah\u00E1jen\u00ED terapie interferonem beta. \u00DA\u010Dinnost terapie interferonem beta \u00FAzce souvis\u00ED s expres\u00ED \u010Di naopak s inhibic\u00ED exprese skupiny kl\u00ED\u010Dov\u00FDch gen\u016F. Korelace exprese gen\u016F s klinick\u00FDm efektem a MRI v\u00FDvojem umo\u017En\u00ED v\u010Das odhalit nonresponsivitu na terapii interferonem beta, v\u010Das zav\u00E9st intenzivn\u011Bj\u0161\u00ED terapii a p\u0159edej\u00EDt nevratn\u00FDm \u0161kod\u00E1m na nervov\u00E9 tk\u00E1ni. V\u010Dasn\u00E1 a dostate\u010Dn\u00E1 terapie sclerosis multiplex je jedinou mo\u017Enost\u00ED, jak p\u0159edej\u00EDt trval\u00E9mu neurologick\u00E9mu deficitu a zachovat kvalitu \u017Eivota nemocn\u00FDch." . . "2010-06-30+02:00"^^ . "http://www.isvav.cz/projectDetail.do?rowId=1A8713"^^ . "2012-01-10+01:00"^^ . "1A8713" . . "6"^^ . . "6"^^ . . . . . "Pharmacogenomics - a promising way for reasonable and efficacious multiple sclerosis treatment"@en . . . . "2005-08-01+02:00"^^ . . . "0"^^ . . "Created biggest DNA bank in central Europe. 16 MS susceptibility loci assessed. Environmental risk factors assessed.Weighted genetic risk score (wGRS) created, that can make a contribution to algorithms for prediction of diagnosis of MS in risk patients"@en . . . . " pharmacogenomics" . "1"^^ . "1"^^ . " DNA" . . "multiple sclerosis; pharmacogenomics; interferon beta; clinically isolated syndrome; DNA; RNA"@en . "Observation of seleted genes expression in patients with the first attack of neurological symptomatology suspected of multiple sclerosis development before and after the initiation of interferon beta treatment. Efficacy of interferon beta treatment is closely in correlation with expression or inhibition of a group of crucial genes. Correlation between gene expression, clinical effect and MRI changes bring the possibility early to detect non-responsiveness to interferon beta treatment, intesify the therapy and so prevent irreversible damage of the central nervous system. Early nad sufficient multiple sclerosis treatment is the only possible way how to prevent permanent neurological deficit and to preserve patients quality of life."@en . "multiple sclerosis" . . " clinically isolated syndrome" . " interferon beta" . . "Farmakogenomick\u00FD p\u0159\u00EDstup ke studiu \u00FA\u010Dinnosti l\u00E9\u010Dby u nemocn\u00FDch s roztrou\u0161enou sklerozou mozkom\u00ED\u0161n\u00ED" . "Vybudov\u00E1na nejrozs\u00E1hlej\u0161\u00ED DNA bank ve st\u0159edn\u00ED Evrop\u011B,Hodnoceno 16 lokus\u016F spojovan\u00FDch s vn\u00EDmavost\u00ED k RS. Hodnocena kombinace genetick\u00FDch a environment\u00E1ln\u00EDch faktor\u016F. Vytvo\u0159eno 7 kategori\u00ED genetick\u00E9ho rizika RS. Vznikl algoritmus pro klinickou praxi."@cs .