. "children; diabetes mellitus type 1; arterial stiffness; pulse wave velocity; ambulatory blood pressure moni; ambulatory arterial stiffness; echocardiography; microalbuminuria"@en . . . "2057"^^ . "2013-05-01+01:00"^^ . . . . "Tuhost c\u00E9v u d\u011Bt\u00ED s diabetem mellitem 1.typu - vztah rychlosti pulzn\u00ED vlny (PWV) a indexu ambulatorn\u00ED arteri\u00E1ln\u00ED tuhosti (AASI)"@cs . "0"^^ . "2015-12-31+01:00"^^ . . "1"^^ . . "Arterial stiffness in children with diabetes mellitus type 1 - relationship between pulse wave velocity (PWV) and ambulatory arterial stiffness index (AASI)"@en . "0"^^ . "1"^^ . "Pulse wave velocity (PWV) is non-invasive measurement of arterial stiffness, which is associated with cardiovascular risks. Even in children, some disease e.g. diabetes and hypertension could lead to increased arterial stiffness. As in adults, PWV measurement has some limits in children (1, 2); therefore, more available and straightforward method has been researched. Recently, AASI (ambulatory arterial stiffness index) has been proposed as a surrogate measure, which could be calculated from ambulatory blood pressure meassurement (ABPM) (3,4). In adults, increased AASI is associated with cardiovascular morbidity and mortality (5,6). The increased AASI was also detected in hypertensive children (4,7). Establishment of correlation between both PWV and AASI could validate AASI as adequate surrogate method for arterial stiffness evaluation even in children. Association of stiffness and signs of early target damage could determine the risk groups of children with T1DM (7, 8), which is necessary to heal."@en . "0"^^ . "Rychlost pulzn\u00ED vlny (PWV) je neinvazivn\u00ED vy\u0161et\u0159en\u00ED tuhosti c\u00E9v, kter\u00E1 je spojena se zv\u00FD\u0161enou kardiovaskul\u00E1rn\u00ED mortalitou v dosp\u011Blosti. N\u011Bkter\u00E1 onemocn\u011Bn\u00ED jako diabetes mellitus 1. typu a hypertenze mohou v\u00E9st i u d\u011Bt\u00ED k zv\u00FD\u0161en\u00E9 tuhosti c\u00E9v. Metoda PWV m\u00E1 ale u d\u011Bt\u00ED i dosp\u011Bl\u00FDch ur\u010Dit\u00E1 omezen\u00ED (1, 2). To je d\u016Fvod pro hled\u00E1n\u00ED jin\u00E9, jednodu\u0161\u0161\u00ED a dostupn\u011Bj\u0161\u00ED metody pro klinickou praxi. Jako n\u00E1hradn\u00ED metoda byl navr\u017Een AASI (ambulatory arterial stiffness index) vypo\u010Dten\u00FD ze z\u00E1znamu 24hodinov\u00E9ho monitorov\u00E1n\u00ED krevn\u00EDho TK (3, 4). Zv\u00FD\u0161en\u00E9 AASI je v dosp\u011Bl\u00E9m v\u011Bku spojeno s kardiovaskul\u00E1rn\u00ED morbiditou a mortalitou (5, 6) a zv\u00FD\u0161en\u00E9 hodnoty byly potvrzeny i u d\u011Bt\u00ED s hypertenz\u00ED (4, 7). Pr\u016Fkaz korelace mezi PWV a AASI by podpo\u0159ilo vyu\u017E\u00EDv\u00E1n\u00ED AASI k hodnocen\u00ED arteri\u00E1ln\u00ED tuhosti v b\u011B\u017En\u00E9 praxi. Vztah PWV a AASI k mark\u00E9r\u016Fm \u010Dasn\u00E9ho po\u0161kozen\u00ED c\u00EDlov\u00FDch org\u00E1n\u016F u d\u011Bt\u00ED s T1DM m\u016F\u017Ee v\u00E9st k nalezen\u00ED rizikov\u00FDch skupin d\u011Btsk\u00FDch diabetik\u016F (T1DM) a k hled\u00E1n\u00ED preventivn\u00EDch a l\u00E9\u010Debn\u00FDch opat\u0159en\u00ED."@cs . . . . "1951"^^ . .