. "3"^^ . "Adaptace \u010Dlov\u011Bka na \u017Eivot v periodicky prom\u011Bnn\u00E9m prost\u0159ed\u00ED zahrnuje \u010Dasov\u00E9 \u0159\u00EDzen\u00ED fyziologick\u00FDch funkc\u00ED tak, \u017Ee mnoh\u00E9 z nich vykazuj\u00ED rytmy s cirkadi\u00E1nn\u00ED periodou. Porucha \u010Dasov\u00E9ho syst\u00E9mu m\u016F\u017Ee m\u00EDt v\u00E1\u017En\u00E9 n\u00E1sledky pro zdrav\u00ED \u010Dlov\u011Bka a je v sou\u010Dasnosti spojov\u00E1na se vznikem \u0159ady civiliza\u010Dn\u00EDch chorob. C\u00EDlem projektu je zav\u00E9st novou neinvazivn\u00ED metodu stanoven\u00ED stavu vnit\u0159n\u00EDho \u010Dasov\u00E9ho syst\u00E9mu \u010Dlov\u011Bka a n\u00E1sledn\u011B ov\u011B\u0159it jej\u00ED vhodnost ke zji\u0161t\u011Bn\u00ED \u00FA\u010Dasti tohoto syst\u00E9mu u n\u011Bkter\u00FDch psychick\u00FDch chorob, jako je rekurentn\u00ED depresivn\u00ED porucha a bipol\u00E1rn\u00ED afektivn\u00ED porucha. U zdrav\u00FDch a nemocn\u00FDch jedinc\u016F bude sledov\u00E1n denn\u00ED rytmus v expresi hodinov\u00FDch gen\u016F ve vzorc\u00EDch z \u00FAstn\u00ED sliznice. Z\u00EDskan\u00E9 v\u00FDsledky umo\u017En\u00ED u ka\u017Ed\u00E9ho jedince p\u0159\u00EDmo na genov\u00E9 \u00FArovni rozpoznat p\u0159\u00EDpadn\u00E9 abnormality funk\u010Dn\u00EDho stavu cirkadi\u00E1nn\u00EDho syst\u00E9mu. V\u00FDsledky t\u011Bchto stanoven\u00ED mohou slou\u017Eit jako diagnostick\u00E9 krit\u00E9rium poruch cirkadi\u00E1nn\u00EDho syst\u00E9mu, kter\u00E9 jsou sou\u010D\u00E1st\u00ED \u0159ady patofyziologick\u00FDch stav\u016F, a p\u0159\u00EDpadn\u011B pomoci p\u0159i jejich l\u00E9\u010Db\u011B a prevenci."@cs . "2010-09-01+01:00"^^ . . "1"^^ . "2013-12-31+01:00"^^ . "0"^^ . "Ur\u010Den\u00ED funk\u010Dn\u00EDho stavu cirkadi\u00E1nn\u00EDho syst\u00E9mu \u010Dlov\u011Bka a jeho zm\u011Bny u depresivn\u00ED a bipol\u00E1rn\u00ED poruchy"@cs . . "Circadian system; clock gene; melatonin; depression"@en . . "3408"^^ . "3408"^^ . . . . . "Adaptation to periodically varying environment includes temporal control of physiological functions, so that many of them exhibit circadian rhythms. Failure of the temporal control may have serious consequences for human health and is currently associated with the emergence of a number of lifestyle diseases. The project aims to introduce a new non-invasive method of analyzing the overall state of the human circadian system and test its suitability to assess involvement of this system in certain diseases such as recurrent depression and bipolar affective disorder. The clock gene expression rhythms will be monitored in samples from the oral mucosa in healthy subjects and patients. The profiles will allow direct detection of any abnormalities in functional status of the circadian system of each individual at genetic level. The results may serve as a diagnostic criterion of circadian disorders, which are involved in various pathological states, and possibly help with their treatment and prevention."@en . . "3"^^ . "1"^^ . . "Determination of functional state of the human circadian system and its changes in depression and bipolar disorder"@en . .