"Kardiovaskul\u00E1rn\u00ED apar\u00E1t pat\u0159\u00ED bezpochyby mezi syst\u00E9mov\u00E9 soustavy, u kter\u00FDch se z\u00E1sadn\u00EDm zp\u016Fsobem uplat\u0148uje vliv pohlav\u00ED na \u0159adu struktur\u00E1ln\u00EDch i metabolick\u00FDch vlastnost\u00ED. Ty pak mohou v\u00E9st k odli\u0161n\u00E9 odpov\u011Bdi na nejr\u016Fzn\u011Bj\u0161\u00ED fyziologick\u00E9 i patologick\u00E9 podn\u011Bty. P\u0159edm\u011Btem na\u0161eho v\u00FDzkumu je apopt\u00F3za v myokardu a hlavn\u011B jej\u00ED zm\u011Bny po transplantaci srdce v z\u00E1vislosti na pohlav\u00ED d\u00E1rce \u010Di p\u0159\u00EDjemce.Vzorky budeme odeb\u00EDrat z prav\u00E9 komory srde\u010Dn\u00ED jednak peropera\u010Dn\u011B p\u0159\u00EDmou biopsi\u00ED, poopera\u010Dn\u011B budou vzorky odeb\u00EDr\u00E1ny p\u0159i pravideln\u00FDch kardiologick\u00FDch kontrol\u00E1ch, u kter\u00FDch bude pl\u00E1novan\u00E1 EMB.Z odebran\u00FDch vzork\u016F bude p\u0159\u00EDtomnost apopt\u00F3zy hodnocena pomoc\u00ED metody TUNEL, anti a proapoptotick\u00FDch protein\u016F(bcl-2, kasp\u00E1za 3)a taky elekron.mikroskopi\u00ED."@cs . "1"^^ . "2014-12-31+01:00"^^ . . . "apoptosis; heart transplantation; sex differences"@en . "Pohlavn\u00ED rozd\u00EDly v apopt\u00F3ze v myokardu u pacient\u016F po transplantaci srdce"@cs . "4720"^^ . "Cardiovascular apparatus undoubtedly belongs to the systems where gender differences play an important role and can influence many structural and metabolic features. Nevertheless, knowledge about the tolerance to cold ischemia in the donor male and female myocardium and myocardium response during specific conditions such as transplantation female heart to men or men heart to female does not exist for the present. The present project is therefore focus on the gender differences of the apoptosis in the myocardium at patients after heart transplantation. The samples of the myocardium will be taken from right ventricle. Perioperative biopsy will be taken under direct vision, postoperative samples will be obtained by routine cardiology check-ups using endomyocardial biopsy. The frequency and amount of apoptotic cells will be assessed by TUNEL and electron microscopy; antiapoptotic and proapoptotic proteins (Bcl-2, caspase 3) will be determined imunohistochemically."@en . . . "4720"^^ . "0"^^ . "0"^^ . "0"^^ . "Myocardial Apoptosis at The Patients After Heart Transplantation: Gender Differences"@en . "2010-09-01+01:00"^^ . . . . "0"^^ . . . .