. "2009-01-01+01:00"^^ . . "0"^^ . "It a large cohort of patients we hope to confirm our findings that high expression and polymorfim of MDR1 cause lower effects of taxane and doxorubicin chemotherapy in breast cancer and extend the study to other ABC transporters (MRP1, BCRP). We will extend this study to ovarian cancer, where taxanes belong to most important drugs. The determination of expression in affected lymph nodes may help to predict the risk of relapse it relation to the used chemotherapy. In fresh breast cancer slices we will continue our pilot study relating taxane transport to expression of MDR1 mRNA and protein to indicate whether MDR1 expression may predict drug efflux from tumor cells and thereby possible lower therapeutic effects. We want to confirm the data that KIF14 expression is an efficient prognostic factor in breast cancer, extend the study to ovarian cancer and to investigate its use in prediction and possible relation to taxane effects in vitro."@en . . "Resistence n\u00E1dor\u016F prsu a ovari\u00ED na cytostatika vyvolan\u00E1 ABC transport\u00E9ry a vztah kinesin\u016F k progn\u00F3ze a predikci v\u00FDvoje nemoci"@cs . "1"^^ . "4"^^ . . . "breast cancer; ovarian cancer; ABC transporters; multidrug resistance; KIF14; proliferation; prognosis; prediction"@en . "2"^^ . "Resistance of breast and ovarian cancer to cytostatics due to ABC transporters and relation of kinesins to prognosis and prediction"@en . . "Chceme potvrdit na velk\u00E9m souboru pacientek n\u00E1\u0161 n\u00E1lez \u017Ee vysok\u00E1 exprese a polymorfimus MDR1 p\u016Fsob\u00ED ni\u017E\u0161\u00ED \u00FA\u010Dinky chemoterapie rakoviny prsu taxany a doxorubicinem a roz\u0161\u00ED\u0159it tuto studii o expresi a polymorfismy dal\u0161\u00EDch ABC transport\u00E9r\u016F (MRP1, BCRP). Nov\u011B chceme studovat expresi ABC transport\u00E9r\u016F u rakoviny ovari\u00ED, je\u017E by mohla sn\u00ED\u017Eit \u00FA\u010Dinky zde nejv\u00FDznamn\u011Bj\u0161\u00EDch cytostatik taxan\u016F a doxorubicinu. Sledov\u00E1n\u00EDm exprese v posti\u017Een\u00FDch uzlin\u00E1ch chceme p\u0159isp\u011Bt k predikci rizika relapsu podle pou\u017Eit\u00E9 terapie. V \u0159ezech lidsk\u00FDch n\u00E1dor\u016F prsu chceme sledovat transport cytostatik ve vztahu k expresi mRNA a proteinu MDR1 pro potvrzen\u00ED vztahu mezi nimi a t\u00EDm uk\u00E1zat zda lze pou\u017E\u00EDt expresi mRNA jako index transportu cytostatik z bun\u011Bk a t\u00EDm predikci ni\u017E\u0161\u00EDch \u00FA\u010Dink\u016F. Chceme potvrdit v\u00FDznam nov\u00E9ho indexu proliferace kinesinu KIF14 pro progn\u00F3zu rakoviny prsu, zjistit jeho v\u00FDznam pro predikci, zkoumat ob\u011B mo\u017Enosti u rakoviny ovari\u00ED a studovat in vitro jeho roli v \u00FA\u010Dinc\u00EDch taxan\u016F je\u017E vyvol\u00E1vaj\u00ED u bun\u011Bk identick\u00E9 projevy"@cs . "4"^^ . . . . . "8236"^^ . . "8236"^^ . . "2011-12-31+01:00"^^ .