. "2009-01-01+01:00"^^ . "5405"^^ . "0"^^ . "Stanoven\u00ED hladiny cytokin\u016F a kostimula\u010Dn\u00EDch molekul v plasm\u011B, kostn\u00ED d\u0159eni, leukocytech a n\u00E1dorov\u00FDch bu\u0148k\u00E1ch nemocn\u00FDch s hematologick\u00FDmi malignitami a jejich vztah k aktivit\u011B nemoci, transplantaci krvetvorby, rozvoji komplikac\u00ED (GvHD) a riziku relapsu."@cs . "Cytokiny jsou fyziologick\u00E9 molekuly proteinov\u00E9 povahy, kter\u00E9 sv\u00FDm p\u016Fsoben\u00EDm v\u00FDznamn\u011B ovliv\u0148uj\u00ED homeost\u00E1zu organismu. Patofyziologick\u00E9 d\u011Bje na \u00FArovni bun\u011Bk jsou spojeny s vyplavov\u00E1n\u00EDm z\u00E1n\u011Btov\u00FDch medi\u00E1tor\u016F a molekul s nimi asociovan\u00FDch, kter\u00E9 mohou ovliv\u0148ovat dal\u0161\u00ED bun\u011B\u010Dn\u00E9 d\u011Bje autokrinn\u011B a parakrinn\u011B. V sou\u010Dasn\u00E9 dob\u011B stoj\u00ED v pop\u0159ed\u00ED z\u00E1jmu experiment\u00E1ln\u00ED medic\u00EDny d\u00EDky jejich vz\u00E1jemn\u00E9mu ovliv\u0148ov\u00E1n\u00ED, propojen\u00ED funkc\u00ED, pleiotropn\u00EDmu p\u016Fsoben\u00ED a redundanci. Stanoven\u00ED koncentrac\u00ED cytokin\u016F v plasm\u011B \u010Di kostn\u00ED d\u0159eni m\u016F\u017Ee odr\u00E1\u017Eet lok\u00E1ln\u00ED \u010Di glob\u00E1ln\u00ED odpov\u011B\u010F organismu na n\u00E1dor. Spole\u010Dn\u011B s kostimula\u010Dn\u00EDmi molekulami mohou slou\u017Eit jako prediktory odpov\u011Bdi na onkologickou l\u00E9\u010Dbu, rizika relapsu \u010Di progn\u00F3zy a rovn\u011B\u017E souviset s predikc\u00ED komplikac\u00ED po transplantaci krvetvorby (GvHD). Tato pr\u00E1ce si d\u00E1v\u00E1 za c\u00EDl tyto prediktory identifikovat."@cs . . "1"^^ . "Determination of concentration of cytokines in plasma, bone marrow, leukocytes and tumor cells of patients with hematological malignancies and their relationship to the disease activity, transplantation, complications (GvHD) and the risk of relapse."@en . "2011-12-31+01:00"^^ . . "7030"^^ . . . . . . . "Cytokines are physiological molecules with protein characteristics, which influence the homeostasis of an organism significantly by their effect. Pathophysiological actions on the cellular level are related to the production of the inflammatory mediators and associated molecules, which can influence other cell regulations autocrinally and paracrinally. Nowadays, they stand in the foreground of interest of the experimental medicine owing to their reciprocal influence, connection of functions, pleiotropic effect and redundance. Determination of their concentration in plasma or bone marrow can reflect the local or the global response of the organism to the tumor. Cytokines and the co-stimulatory molecules can serve as predictors of the response to the oncology treatment, risk of relapse or prognosis, and they can be united with prediction of complications after transplantation of hematopoiesis (GvHD). The aim of this work is to identify these predictors."@en . "1"^^ . . "7"^^ . "cytokines; ELISA; flow cytometry; GvHD; transplantation; leukemia; lymphoma"@en . "7"^^ .