"The project is focused on the extension of our knowledge about pathophysiology of the development and progression of peripheral neuropathy and neuropathic pain from the initial stages of diabetes mellitus type 2 (DM2). A group of patients with recent DM2 will prospectively be followed for two years using the evaluation of clinical signs and symptoms, battery of neurophysiological methods and the assessment of the intra- and subepidermal nerve fiber density in skin biopsy samples. Simultaneously, the influence of some factors which are supposed to play a role in pathophysiology of diabetic neuropathy (i.e.cytokines, neurotrophins, impaired regeneration, specific pattern and proportion of various types of affected fibers and the sequence of their involvement) will be assessed."@en . . "3213"^^ . . . . . "9"^^ . "Projekt je zam\u011B\u0159en na roz\u0161\u00ED\u0159en\u00ED poznatk\u016F o patofyziologii vzniku a rozvoje perifern\u00ED neuropatie a neuropatick\u00E9 bolesti v inici\u00E1ln\u00EDch st\u00E1di\u00EDch diabetu mellitu (DM). Bude realizov\u00E1n pomoc\u00ED prospektivn\u00EDho sledov\u00E1n\u00ED souboru pacient\u016F s recentn\u011B diagnostikovan\u00FDm DM, u nich\u017E bude po dobu 2 let hodnocen klinick\u00FD n\u00E1lez, v\u00FDsledky souboru neurofyziologick\u00FDch metod a n\u00E1lez intra- a subepiderm\u00E1ln\u00ED hustoty nervov\u00FDch vl\u00E1ken z ko\u017En\u00ED biopsie. U sledovan\u00FDch pacient\u016F bude posouzen v\u00FDznam n\u011Bkter\u00FDch faktor\u016F, u nich\u017E se p\u0159edpokl\u00E1d\u00E1 role v etiopatogenezi bolestiv\u00E9 diabetick\u00E9 neuropatie (vliv cytokin\u016F, neurotrofin\u016F, zm\u011Bn regenerace, pom\u011Bru a \u010Dasov\u00E9ho sledu posti\u017Een\u00ED r\u016Fzn\u00FDch typ\u016F nervov\u00FDch vl\u00E1ken)."@cs . "9"^^ . "Painful diabetic neuropathy"@en . "Bolestiv\u00E1 diabetick\u00E1 neuropatie"@cs . . . "1"^^ . "3138"^^ . "2009-01-01+01:00"^^ . . "0"^^ . . . "diabetic neuropathy; pain; small nerve fibers; thermal sensation; skin biopsy; regeneration; cytokines; PCR"@en . "1"^^ . "2011-12-31+01:00"^^ . .