"The aim of the study will be to the dynamics of selected cytokines and other parameters of the perioperative tissue response and specialy their impact on the pulmonary vascular resistence, the residual pulmonary hypertension, infectious and other complications in the early postoperative period. Proposed study is a follow-up to a pilot study of 10 patients undergoing PEA last year in our institution. The results of this study were accepted for presentation on International Asian Cardiovascular Congress in Osaca in June 2006. Propose study will be focused on dynamics of selected cytokines in an effort to increase our knowledge concerning the cytokine network specially in the final phase of operation and immediately after that. We will also monitor NO and its products. We suppose the knowledge got from these project might contribute to therapeutic intervention and improvement of prognosis of other types of pulmonary hypertension too."@en . . "\u00DAloha cytokin\u016F v periopera\u010Dn\u00EDm pr\u016Fb\u011Bhu chirurgick\u00E9 l\u00E9\u010Dby nemocn\u00FDch s plicn\u00ED hypertenz\u00ED"@cs . . "C\u00EDlem studie bude zjistit dynamiku a v\u00FDznam cytokin\u016F pro poopera\u010Dn\u00ED tk\u00E1\u0148ovou odezvu a jejich vliv na plicn\u00ED hemodynamiku,zejm\u00E9na na vaskul\u00E1rn\u00ED rezistenci, rezidu\u00E1ln\u00ED plicn\u00ED hypertenzi,d\u00E1le pak v\u00FDskyt komplikac\u00ED a progn\u00F3zu pacienta v \u010Dasn\u00E9m poopera\u010Dn\u00EDm obdob\u00ED. P\u0159edpokl\u00E1d\u00E1me \u017Ee z\u00EDskan\u00E9 znalosti mohou p\u0159isp\u011Bt k terapeutick\u00E9mu ovlivn\u011Bn\u00ED i ostatn\u00EDch typ\u016F plicn\u00ED hypertenze. Navrhovan\u00E1 studie navazuje na poznatky pilotn\u00ED studie proveden\u00E9 na 10 nemocn\u00FDch s PEA v minul\u00E9m roce jej\u00ED\u017E v\u00FDsledky byli p\u0159ijaty k presentaci na Mezin\u00E1rodn\u00ED Asijsk\u00FD Kardiovaskul\u00E1rn\u00ED kongres v Osace v \u010Dervnu 2006 zam\u011B\u0159enou na dynamiku vybran\u00FDch cytokin\u016F, ve snaze roz\u0161\u00ED\u0159it znalosti o chov\u00E1n\u00ED cytokinov\u00E9 s\u00EDt\u011B zejm\u00E9na v z\u00E1v\u011Bre\u010Dn\u00E9 f\u00E1zi operace a bezprost\u0159edn\u011B po n\u00ED. Sou\u010Dasn\u011B budeme sledovat NO a jeho produkty a zam\u011B\u0159\u00EDme se i na vliv ultrafiltrace na hladiny cytokin\u016F."@cs . . "Role of cytokines in perioperative process of surgical treatment patients with pulmonary hypertension"@en . "3060"^^ . "0"^^ . "0"^^ . "1"^^ . . . "3009"^^ . . . . . "2007-01-01+01:00"^^ . "Pulmonary hypertension; cytokines; acute phase proteins; pulmonary endarterectomy; hypothermia; ultrafiltration"@en . . "14"^^ . "2009-12-31+01:00"^^ . "14"^^ .