"1"^^ . "HIV infection; cytokine; ELISPOT; MHC tetramers; T lymfocytes????; HAART; LTNPs; IMMUNITY?"@en . . "Analysis of clinical status and immune functions of HIV positive individuals without progression of the disease and patients not responding to antiretroviral treatment; the determination of immune protection correlates in evolution of HIV infection."@en . . "Anal\u00FDza klinick\u00E9ho stavu a imunitn\u00EDch funkc\u00ED u HIV+ jedinc\u016F bez dlouhodob\u00E9 progrese(LTNPs) a u nereaguj\u00EDc\u00EDch odpov\u00EDdaj\u00EDc\u00EDm zp\u016Fsobem na sou\u010Dasnou l\u00E9\u010Dbu v podm\u00EDnk\u00E1ch \u010CR s pomoc\u00ED stanoven\u00ED HIV specifick\u00FDch T lymfocyt\u016F - jejich po\u010Dtu a funkce. Zaveden\u00ED nov\u00FDch metod umo\u017Enuj\u00EDch studium po\u010Dtu a funkce specifick\u00FDch T lymfocyt\u016F - MHC tetram\u00E9ry a ELISPOTy. Anal\u00FDza nov\u011B zaveden\u00FDch a standardn\u00EDch vy\u0161et\u0159en\u00ED imunitn\u00EDho syst\u00E9mu u jedinc\u016F bez dlouhodob\u00E9 progrese (LTNPs) a u pacient\u016F nereaguj\u00EDch na terapii. Stanoven\u00ED vhodn\u00FDch imunologick\u00FDch korel\u00E1t\u016F, nov\u00FDch marker\u016F progrese HIV infekce zp\u0159esn\u00ED predikci klinick\u00E9ho v\u00FDvoje, optimalizuje \u010Dasov\u00FD moment pro nasazen\u00ED pop\u0159. p\u0159eru\u0161en\u00ED antiretrovirov\u00E9 terapie nebo vy\u00FAst\u00ED do dal\u0161\u00EDch l\u00E9\u010Debn\u00FDch postup\u016F-nap\u0159.imunoterapie"@cs . . . . "Analyzing clinical status and immune functions of HIV+ individuals without long-term progression (LTNPs) and patients not responding satisfactory to therapy with monitoring the numbers and function of HIV-specific T lymphocytes. Introducing new methods for evaluation of number and function of specific T lymphocytes - MHC tetramers and ELISPOTs. Analyzing results of new and standard immunological tests of individuals without long-term progression (LTNPs) and of patients not responding to therapy. Determination of applicable immunological new markers improve the prediction of the evolution of HIV infection and optimize the indication of the start (or interruption) of antiretroviral treatment or iniciate other possibilities - e.g. immunotherapy."@en . "1"^^ . "0"^^ . "1611"^^ . . "1442"^^ . . "1"^^ . . "Anal\u00FDza klinick\u00E9ho stavu a imunitn\u00EDch funkc\u00ED u HIV+ jedinc\u016F bez dlouhodob\u00E9 progrese a u pacient\u016F nereaguj\u00EDc\u00EDch odpov\u00EDdaj\u00EDc\u00EDm zp\u016Fsobem na st\u00E1vaj\u00EDc\u00ED l\u00E9\u010Dbu, se snahou o stanoven\u00ED korel\u00E1tu imunity v evoluci HIV infekce"@cs . "0"^^ . .