"The role of genetic factors in susceptibility to alcoholic liver disease"@en . . . . . "1557"^^ . "\u00DAloha d\u011Bdi\u010Dn\u00FDch faktor\u016F v etiologii a patogeneze alkoholick\u00E9 nemoci jater."@cs . . "The aim of the proposed study is to find combination(s) of genetic variants in 7 genes responsible for the genetic disposition to the development or serious course of ALD. Twelve polymorphisms in the 7 key genes will be analysed in min. 200 patients with ALD and 450 healthy controls. The obtained allelic frequencies will be evaluated by statistical methods."@en . "0"^^ . "alcohol; endotoxin; cirrhosis; Kupffer cells; oxidative stress; TNF-alfa; SOD2; UCP2"@en . "1"^^ . "0"^^ . "1557"^^ . . . "1"^^ . . . "C\u00EDlem studie je nalezen\u00ED kombinac\u00ED genetick\u00FDch variant 7 gen\u016F zodpov\u011Bdn\u00FDch za d\u011Bdi\u010Dnou dispozici k rozvoji alkoholov\u00E9ho po\u0161kozen\u00ED jater (ALD), kter\u00E9 p\u0159edstavuj\u00ED zv\u00FD\u0161en\u00E9 riziko pro vznik \u010Di z\u00E1va\u017En\u00FD pr\u016Fb\u011Bh ALD. U 200 pacient\u016F s ALD a ve dvojn\u00E1sobn\u00E9m vzorku kontroln\u00ED populace bude provedena anal\u00FDza 12 polymorfism\u016F v 7 kl\u00ED\u010Dov\u00FDch genech. Nalezen\u00E9 frekvence alel u pacient\u016F a kontrol budou porovn\u00E1ny statistick\u00FDmi metodami."@cs . "1"^^ . . .