"Detection of the rate of apoptosis in native cell subpopulations and in cultured cells obtained ftom patiens with different stages of myelodysplastic syndrome. Investigation of the role the rate of apoptosis in prognosis,prediction of leulemic progession and clinical manifestation of different forms of MDS. Evaluation of the results obtained in short term cultures with antiapoptotic agents for their rational indication in the treatment of MDS."@en . . "2744"^^ . "0"^^ . . "2851"^^ . . . "myelodysplasia;apoptosis;CD 34+cells;glykophotin A+;cell cultires;erythropoietin;G-CSF;amifostine"@en . . "17"^^ . "Zji\u0161t\u011Bn\u00ED stupn\u011B apotosy bun\u011B\u010Dn\u00FDch subpopulac\u00ED isolovan\u00FDch ze d\u0159en\u011B nemovn\u00FDch s r\u016Fzn\u00FDmi st\u00EDdii myelodysplastick\u00E9ho syndromu v nativn\u00EDm stavu a po kr\u00E1tkodob\u00E9 kultivaci. Sledov\u00E1n\u00ED v\u00FDznamu stupn\u011B apoprosy pro prognosu nemocn\u00FDch,predikci leukemizace procesu a klinick\u00E9 projevy onemocn\u011Bn\u00ED. Zkoum\u00E1n\u00ED mo\u017Enosti racion\u00E1ln\u00EDho vyu\u017Eit\u00ED l\u00E1tek ovliv\u0148uj\u00EDc\u00EDch stupe\u0148 bun\u011B\u010Dn\u00E9 apoptosy na podklad\u011B jejich \u00FA\u010Dinku in vitro v kr\u00E1tkodob\u00FDch kultur\u00E1ch bun\u011B\u010Dn\u00FDch subpopulac\u00ED nemocn\u00FDch s myelodysplastick\u00FDm syndromem."@cs . "17"^^ . "0"^^ . . . . "1"^^ . "V\u00FDznam sledov\u00E1n\u00ED apoptosy pro patogenezu,prognozu a l\u00E9\u010Debn\u00E9 ovlivn\u011Bn\u00ED myelodysplastick\u00E9ho syndromu."@cs . . "The role of apoptosis in pathogenesis,prognosis and treatment of myelodysplastic syndrome"@en .