. "U pacient\u016F s Huntingtonovou nemoc\u00ED (HN) sledovan\u00FDch v Extrapyramidov\u00E9m centru bude provedena MRI volumometrie (baz\u00E1ln\u00ED ganglia, front\u00E1ln\u00ED laloky) a anal\u00FDza obsahu \u017Eeleza v mozku. Tyto parametry budou porovn\u00E1v\u00E1ny s normami. Pacienti budou vy\u0161et\u0159eni psychologick\u00FDmi testy zam\u011B\u0159en\u00FDmi p\u0159edev\u0161\u00EDm na exekutivn\u00ED funkce a pam\u011B\u0165. Kognitivn\u00ED deteriorace bude tak\u00E9 hodnocena kognitivn\u00EDmi zrakov\u00FDmi potenci\u00E1ly. Hodnocena bude neurologick\u00E1 symptomatika pomoc\u00ED \u0161k\u00E1ly UHDRS. Z\u00EDskan\u00E1 data u nemocn\u00FDch i zdrav\u00FDch subjekt\u016F budou vyhodnocena pomoc\u00ED standardn\u00EDch statistick\u00FDch metod. Na z\u00E1klad\u011B anal\u00FDzy vz\u00E1jemn\u00FDch vztah\u016F budou vybr\u00E1ny metody vhodn\u00E9 pro \u010Dasn\u00E9 ukazatele HN, ur\u010Den p\u0159\u00EDnos jednotliv\u00FDch metod pro diagnostiku a sledov\u00E1n\u00ED rozvoje HN a definov\u00E1n vztah posti\u017Een\u00ED baz\u00E1ln\u00EDch gangli\u00ED k hybn\u00FDm a ment\u00E1ln\u00EDm sympton\u016Fm HN."@cs . . "8"^^ . . "Huntington\u00B4s Disease;basal ganglia;CAG repeats;volumometry;neuropsychology;evoked potentials"@en . "40 HD patients will be clinically investigated, the MRI based voxel-wise volumometric analysis of basal ganglia and frontal lobes and depositions of iron will be analysed. 40 healthy volunteers will be used as a control group. All HD patients will be examined by psychological tests and event-related visual evoked potentials. The data obtained in both groups will be analysed by means of standard statistic methods. Specific programs for the image processing, reconstruction and analysis will be used. The relation between clinical, functional and morphometric parameters will be determined, the most sensitive and specific signs of the early stages of HD will be analysed."@en . . . "8"^^ . . . "1"^^ . "2128"^^ . "Huntington\u00B4s disease: Analysis of relation between clinical, functional and morphometric parameters."@en . "0"^^ . "1"^^ . . "Huntingtonova nemoc: Anal\u00FDza souvislost\u00ED mezi klinick\u00FDmi, funk\u010Dn\u00EDmi a morfometrick\u00FDmi n\u00E1lezy."@cs . . "2128"^^ .